jak2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40443	JAK2-IN-6	JAK2-IN-6	JAK
	JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathway...		JAK
T35900	JAK2-IN-7	JAK2-IN-7	JAK
	JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and select...		JAK
T3042	JAK2 Inhibitor V	JAK2 Inhibitor V Z3,Z3	JAK
	JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.		JAK
T8742	G5-7	JAK2 inhibitor G5-7	Apoptosis , JAK
	JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) is an orally active JAK2 inhibitor, selectively inhibits JAK2–mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for g...		Apoptosis , JAK
T71193	Jak2-IN-7j
	Jak2-IN-7j is a selective Jak2 inhibitor which demonstrates a time-dependent knock-down of pSTAT5, which is a downstream target of Jak2.
T11708	JAK2-IN-4		JAK
	JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.		JAK
T19017	JAK2 JH2 Tracer		Others
	JAK2 JH2 Tracer is a fluorescent probe for the JAK2 JH2 domain (Kd: 0.2 μM).		Others
T11707	JAK2/FLT3-IN-1		JNK
	JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, F...		JNK
T79581	JAK2-IN-9		JAK
	Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM. It effectively inhibits the phosphorylation of JAK2, STAT3, and STAT5, possesses metabolic stabilities, and induces apoptosis. This com...		JAK
T64227	JAK2 JH2 binder-1
	JAK2 JH2 binder-1 is a potent and selective JAK2 JH2 binder (Ki: 37.1 nM). JAK2 JH2 binder-1 has the potential to be used in the study of various myeloproliferative neoplasms.
T80921	Tubulin/JAK2-IN-1
	Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant antiproliferative effects against cancer cells [1].
T72754	JAK2/STAT3-IN-1
	JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 µM and demonstrating anti-tumor activity.
T63146	JAK2/TYK2-IN-1
	JAK2/TYK2-IN-2 is a potent and selective inhibitor of TYK2 (IC50: 9 nM) and JAK2 (IC50: 157 nM) with anti-inflammatory effects.
T64104	JAK2/FLT3-IN-1 TFA
	JAK2/FLT3-IN-1 (TFA) is an orally active dual inhibitor of JAK2/FLT3 that exhibits anticancer effects, acting on JAK2 (IC50: 0.7 nM), FLT3 (IC50: 4 nM), JAK1 (IC50: 26 nM) and JAK3 (IC50: 39 nM).
T62317	α7 nAchR-JAK2-STAT3 agonist 1
	α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β...
TP1269	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)	Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9
	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.
T3133	YM-90709	YM90709,YM 90709	IL Receptor , Interleukin
	YM-90709 is a new-type antagonist inhibiting the binding of interleukin-5 to the interleukin-5 receptor.		IL Receptor , Interleukin
T12266	Ilginatinib	NS-018	Tyrosine Kinases , JAK
	Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T71191	Covidcil-19
	Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency i...
T12266L2	Ilginatinib hydrochloride	NS-018 hydrochloride	Tyrosine Kinases , JAK
	Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK