il-1α — TargetMol Chemicals

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Search Results for " il-1α "

Compounds

Cat No.	Product Name	Synonyms	Targets
T8477	IQ-3		JNK
	IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an...		JNK
T76777	Bermekimab	MABp1	IL Receptor
	Bermekimab (MABp1) is a humanized monoclonal antibody against interleukin-1α (IL-1α).Bermekimab has potential anti-inflammatory activity to prevent skin inflammation.		IL Receptor
T3816	Velutin		NF-κB , HIF/HIF Prolyl-Hydroxylase
	Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ...		NF-κB , HIF/HIF Prolyl-Hydroxylase
T77026	Goflikicept
	Goflikicept (RPH 104), a hybrid protein, selectively targets and neutralizes circulating IL-1ß and IL-1α. This compound shows promise for the investigation of ST-segment elevation myocardial infarction (STEMI) [1].
T77077	Lutikizumab
	Lutikizumab (ABT-981) is a dual variable domain immunoglobulin targeting and inhibiting both IL-1α and IL-1β. This compound is under investigation for its potential application in osteoarthritis research [1].
T76772	Nadunolimab
	Nadunolimab, a human monoclonal IgG1 antibody, targets IL1RAP, inhibiting IL-1α and IL-1β signaling and inducing antibody-dependent cellular cytotoxicity. It is utilized in cancer research [1].
T79385	PDE1-IN-5
	PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor with an IC50 of 15 nM, exhibiting anti-inflammatory properties through the inhibition of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 expression induced by LPS. It has demon...
T78822	JT002		NOD-like Receptor (NLR)
	JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLR...		NOD-like Receptor (NLR)
T35697	Lauric Acid-13C
	Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Laur...
T63339	ALV1
	ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal pr...
TN2178	Sanggenone H		IL Receptor , TNF , NF-κB
	Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated macrophages.		IL Receptor , TNF , NF-κB
T36517	Resveratrol-3-O-sulfate sodium
	Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 μM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and d...
T83848	VnP-16 TFA
	VnP-16, a synthetic peptide fragment mirroring amino acids 270-281 of vitronectin (a multifunctional glycoprotein involved in cell attachment, migration, and spreading), promotes attachment and spreading of isolated huma...
T35406	α-MSH TFA
	α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocyt...