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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8958 | PU-H54 | GPR | |
PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94. | |||
T16994 | Pimitespib | TAS-116 | HSP |
Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively). | |||
T2114 | VER-82576 | NVP-BEP800 | HSP |
VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94. | |||
T21872 | CCT018159 | Apoptosis , HSP | |
CCT018159 is a 3,4-diarylpyrazole resorcinol, an ATP-competitive HSP90ATPase inhibitor that inhibits human Hsp90β and yeast Hsp90 with IC50s of 3.2 and 6.6 μM, respectively.CCT018159 inhibits key endothelial and tumor ce... | |||
T6118 | NVP-HSP990 | HSP990 | Apoptosis , HSP |
NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM). | |||
T1989 | Luminespib | AUY922,VER-52296,NVP-AUY922 | Apoptosis , HSP , Autophagy |
Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay). | |||
T15088 | Debio 0932 | CUDC-305 | HSP |
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively). | |||
T69779 | KUNB31 | ||
KUNB31 is a potent and selective inhibitor of Hsp90β. |