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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8838 | CCI-007 | Apoptosis , Histone Methyltransferase | |
CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485 | |||
T13774 | ML390 | Others , Dehydrogenase | |
ML390 exerts its potent differentiation effect on multiple leukemia models. | |||
T28036 | MI-2-2 | MI22,MI 2 2 | Histone Methyltransferase |
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM. | |||
T9102 | WM-3835 | Apoptosis , Histone Methyltransferase , Histone Acetyltransferase | |
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation. | |||
T9958 | DB818 | Others | |
DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression. | |||
T68487 | DB1055 | ||
DB1055 is a novel HOXA9 Transcription Factor Inhibitor, dedemonstrating for the first time the propensity of sequence-selective DNA ligands to inhibit HOXA9/DNA binding. | |||
T73637 | Dot1L-IN-1 TFA | ||
Dot1L-IN-1 TFA is a potent and selective Dot1L inhibitor, characterized by a K i of 2 pM and an IC 50 of <0.1 nM. It effectively inhibits H3K79 dimethylation (IC 50 =3 nM) and suppresses the HoxA9 promoter activity (IC 5... |