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MI-2-2

Catalog No. T28036 CAS 1454920-20-7

Synonyms: MI22, MI 2 2

MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.

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MI-2-2, CAS 1454920-20-7

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 97.00
5 mg	In stock	$ 241.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
In vitro	MI-2-2 is capable of inhibiting the bivalent fragment of MLL that comprises both MBM1 and MBM2 with IC50 of 520 nM. MI-2-2 potently inhibits cell proliferation, differentiation and down-regulation of Hoxa9 expression. MI-2-2 exhibits pronounced activities at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4[1].

Synonyms	MI22, MI 2 2
Molecular Weight	415.5
Formula	C17H20F3N5S2
CAS No.	1454920-20-7

Storage

keep away from direct sunlight,store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Shi A, et al. Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood. 2012;120(23):4461-4469. 2. Ren J, et al. Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4472-6. 3. Vedadi M, et al. Targeting human SET1/MLL family of proteins. Protein Sci. 2017 Apr;26(4):662-676.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MI-2-2 1454920-20-7 Chromatin/Epigenetic Histone Methyltransferase cell proliferation inhibit menin-MLL interaction MI 22 Epigenetic Reader Domain Inhibitor MI-22 Hoxa9 expression differentiation MI22 MI 2 2 leukemia inhibitor

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