fgfr2-in-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T61473	FGFR2-IN-2
	FGFR2-IN-2 is a selective FGFR2 inhibitor with an IC 50 of 29 nM.
T5122	Alofanib	RPT835	Apoptosis , FGFR
	Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR...		Apoptosis , FGFR
T1948	AZD4547		VEGFR , FGFR
	AZD4547, a new-type specific FGFR inhibitor, targets for FGFR1/2/3 (IC50: 0.2/2.5/1.8 nM in cell-free assays).		VEGFR , FGFR
T10372	ARQ 069		Others
	ARQ 069 (3.8-60 μM; for 2 hours) reduces the degree of phosphorylation of FGFR (predominantly FGFR2) in a concentration-dependent manner, without decreasing β-actin. ARQ 069 shows an affinity for FGFR2 of 5.2 μM. ARQ 069...		Others
T3512	S49076 HCl	S-49076 Hydrochloride	FGFR , c-Met/HGFR , TAM Receptor
	S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 HCl potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in ...		FGFR , c-Met/HGFR , TAM Receptor
T62653	FGFR-IN-2
	FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM).
T77816	Deruxtecan analog 2
	Deruxtecan Analog 2 (example 9 P3), a Deruxtecan derivative, serves as an agent-linker conjugate integrating Camptothecin (CPT), a Topo I inhibitor active against colorectal, breast, lung, and ovarian cancers, with a dis...