fc-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22508	3-CPMT	Chlortropbenzyl hydrochloride,3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride,SL6057,Wy 2149,FC-1	Dopamine Receptor
	3-CPMT (FC-1) is a dopamine uptake inhibitor and a potent long-acting antihistaminic agent.		Dopamine Receptor
T3S1591	Notoginsenoside Fc		Others , Autophagy
	1. Notoginsenoside Fc has perfect anti-platelet aggregatory effect.		Others , Autophagy
T9543	Syk Inhibitor II hydrochloride		Others
	The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...		Others
T83063	Anti-IgG-Fc (Human)
	Anti-IgG-Fc (Human) is an antibody targeting the Fc region of human immunoglobulin G1 (IgG1) [1].
T76936	Budigalimab
	Budigalimab (ABBV 181; PR 1648817), a humanized IgG1 monoclonal antibody, specifically targets the programmed cell death 1 (PD-1) receptor. It features an Fc mutation to decrease interactions with the Fc receptor, thereb...
T80598	Davoceticept	CD80 vIgD-Fc,ALPN-202
	Davoceticept (ALPN-202; CD80 vIgD-Fc), a monoclonal antibody that targets CTLA-4, is comprised of the (1-107) fragment of CD80 fused to the IGHG1 Fc domain through a peptidyl linker. It is commonly produced in CHO (Chine...
T68225	Fc 11a-2
	Fc 11a-2, a benzimidazole compound, functions as an orally active, potent inhibitor of the NLRP3 inflammasome. It effectively hinders the NLRP3 inflammasome formation by blocking caspase-1 activation and consequently the...
T77182	Rimteravimab
	Rimteravimab (XVR011) is a bivalent VHH-Fc antibody that exhibits potent neutralizing activity, high stability, broad coverage, and has its Fc effector functions silenced, targeting the disease caused by SARS-CoV-2 [1].
T82502	Efaprinermin alfa	OMP-336B11
	Efaprimermin alfa (OMP-336B11) is a human monoclonal antibody that targets TNFRSF18, and functions as a GITR ligand-Fc fusion protein [1].
T77133	Prolgolimab
	Prolgolimab (BCD-100), a human IgG1 anti-PD-1 monoclonal antibody featuring the Fc-silencing 'LALA' mutation, is utilized in advanced melanoma research [1].
T77175	Efruxifermin
	Efruxifermin, an Fc-FGF21 fusion protein consisting of a human IgG1 Fc domain linked to modified human FGF21, exhibits a prolonged half-life and enhanced receptor affinity compared to its native counterpart. It is utiliz...
T77039	Ipafricept
	Ipafricept (OMP-54F28; FZD8-Fc), a pioneering recombinant fusion protein, incorporates the extracellular segment of the human frizzled-8 receptor and the Fc fragment of human IgG1, targeting the Wnt ligand. It exhibits a...
T82499	Efmoroctocog alfa
	Efmoroctocog alfa, a recombinant human coagulation factor VIII-Fc fusion protein (rFVIIIFc), serves as a therapeutic agent for Hemophilia A research [1].
T63715	HIgG–hFc receptor-IN-1
	hIgG-hFc receptor-IN-1 is a human immunoglobulin G - human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction inhibitor (IC50: 2 μM).
T77055	Lenercept
	Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].
T81624	Obexelimab	XmAb5871
	Obexelimab (XmAb5871) is a humanized Fc-engineered anti-CD19 antibody with enhanced affinity for FcγRIIb, utilized in the study of autoimmune diseases [1].
T82498	Eftansomatropin alfa
	Eftansomatropin alfa, an antibody that targets the growth hormone receptor (GSH), is a fusion protein comprising GH1 and the Fc region of IGHG4 [1].
T76839	Visilizumab
	Visilizumab, a humanized IgG2 monoclonal antibody with low Fc receptor binding affinity, targets the CD3 epsilon (CD3ε) subunit. It is utilized in research related to ulcerative colitis and Crohn's disease [1].
T76821	Ocaratuzumab
	Ocaratuzumab (AME 133v), an Fc-engineered humanized IgG1 anti-CD20 monoclonal antibody, demonstrates enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) [1] [2] with a dissociation constant (Kd) of approximatel...
T78309	Telitacicept	RC18
	Telitacicept (RC18), a fully human TACI-Fc fusion protein, acts as a dual inhibitor of B lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligand), effectively impeding B lymphocyte proliferation. This com...