cdk9 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10745	CDK9-IN-7		CDK
	CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM).		CDK
T10742	CDK9-IN-10		CDK
	CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.		CDK
T9632	CDK9-IN-30		HIV Protease
	CDK9-IN-30 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.		HIV Protease
T118066	CDK9 inhibitor HH1	8019-9719	CDK
	CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.		CDK
T10746	CDK9-IN-8		CDK
	CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).		CDK
T14918	CDK9-IN-2		Others , CDK
	CDK9-IN-2 is a special CDK9 inhibitor and has an IC50 of 5 nM and 7 nM in A2058 skin cell line (72 hours) and H929 multiple myeloma cell line (72 hours), respectively.		Others , CDK
T39354	CDK9-IN-12	CDK9-IN-12
	CDK9-IN-12 displays the optimal CDK9 inhibitory activity with an IC 50 value of 5.41 nM.
T36744	CDK9 Antagonist-1	CDK9 Antagonist-1
	CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form...
T60619	CDK9-IN-15		CDK
	CDK9-IN-15 is a potent small molecule CDK9 inhibitor, which can block the phosphorylation of positive transcription elongation factor b (P-TEFb) on the C-terminal region of RNA Poly-II by degradation and inhibition of CD...		CDK
T39997	PROTAC CDK9 ligand-1	PROTAC CDK9 ligand-1
	PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
T39996	PROTAC CDK9 degrader-4	PROTAC CDK9 degrader-4
	PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9...
T10743	CDK9-IN-11		CDK
	CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].		CDK
T5438	PROTAC CDK9 Degrader-1		CDK
	PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.		CDK
T10741	CDK9-IN-1		CDK
	CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).		CDK
T10747	CDK9-IN-9		CDK
	CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).		CDK
T70400	CDK9/CycT1-IN-93
	CDK9/CycT1-IN-93 is a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.
T17728	PROTAC CDK9 degrader-2		Others
	PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to...		Others
T79037	CDK9-IN-23		CDK
	CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].		CDK
T63054	CDK9-IN-18
	CDK9-IN-18 is a potent inhibitor of CDK9 that blocks the phosphorylation of the kinase CDK9. CDK9-IN-18 exhibits good anticancer activity and low cellular activity and is able to induce apoptosis.
T79704	CDK9-IN-28		CDK
	PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor, serves as a target protein ligand for PROTAC synthesis. Exhibiting substantial anti-proliferative activity in solid tumors [1], this compound is instr...		CDK