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PROTAC CDK9 Degrader-1

Name: PROTAC CDK9 Degrader-1
Brand: TargetMol
SKU: T5438
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5438Cas No. 2118356-96-8

PROTAC CDK9 Degrader-1 is a selective PROTAC CDK9 degrader composed of a cereblon ligand and a CDK9 ligand.

PROTAC CDK9 Degrader-1

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Purity: 95.1%

Catalog No. T5438Cas No. 2118356-96-8

PROTAC CDK9 Degrader-1 is a selective PROTAC CDK9 degrader composed of a cereblon ligand and a CDK9 ligand.

Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$331	In Stock
10 mg	$529	In Stock
25 mg	$858	In Stock
50 mg	$1,180	In Stock
1 mL x 10 mM (in DMSO)	$446	In Stock

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Batch Information

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Purity:95.1%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	PROTAC CDK9 Degrader-1 is a selective PROTAC CDK9 degrader composed of a cereblon ligand and a CDK9 ligand.
In vitro	In HCT116 cells, PROTAC CDK9 Degrader-1 (Compound 3) (2.5-20 μM; 6 h) induced CDK9 degradation in a dose-dependent manner.[1]

Chemical Properties

Molecular Weight	613.66
Formula	C₃₃H₃₅N₅O₇
Cas No.	2118356-96-8
Smiles	O=C(NC1=NNC(=C1)C2CCC2)CC3=CC=C(OCCCCCOC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6)C=C3
Relative Density.	1.390 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (130.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6296 mL	8.1478 mL	16.2957 mL	81.4783 mL
5 mM	0.3259 mL	1.6296 mL	3.2591 mL	16.2957 mL
10 mM	0.1630 mL	0.8148 mL	1.6296 mL	8.1478 mL
20 mM	0.0815 mL	0.4074 mL	0.8148 mL	4.0739 mL
50 mM	0.0326 mL	0.1630 mL	0.3259 mL	1.6296 mL
100 mM	0.0163 mL	0.0815 mL	0.1630 mL	0.8148 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc