cdk8-in-1 — TargetMol Chemicals

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Search Results for " cdk8-in-1 "

Compounds

Cat No.	Product Name	Targets
T10740	CDK8-IN-1	CDK
	CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).	CDK
T10739	CDK8/19-IN-1	CDK
	CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).	CDK
T5405	BI-1347	CDK
	BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.	CDK
T21678	3MB-PP1	PLK
	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi...	PLK
T81137	SNX7886	PROTACs
	SNX7886 is a potent PROTAC (proteolysis-targeting chimera) that effectively degrades CDK8 and CDK19, achieving 90% degradation of CDK8 and 80% degradation of CDK19 in 293 cells [1].	PROTACs
T61742	CDK8-IN-11
	CDK8-IN-11 is a potent and selective inhibitor of CDK8, demonstrating an IC50 of 46 nM, and effectively targets the WNT/β-catenin signaling pathway. This compound has potential applications in colon cancer research [1].
T74784	LL-K8-22
	LL-K8-22 is a potent, selective, and durable dual degrader of CDK8-cyclin C, demonstrating DC50 values of 2.52 and 2.64 μM, respectively. This compound effectively suppresses STAT1 Ser 727 phosphorylation and inhibits ca...