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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T40160 | CDK2-IN-7 | CDK2-IN-7 | |
CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM). | |||
T82759 | CDK2-IN-20 | CDK | |
CDK2-IN-20 (compound 3b), a CDK2 inhibitor, exhibits cytotoxic effects on tumor cells with an IC50 ranging from 5.52-17.09 µM. It arrests the MCF-7 cell cycle at the S phase and induces apoptosis [1]. | |||
T79729 | EGFR/CDK2-IN-4 | EGFR | |
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, demonstrating IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2. It prompts apoptosis in MCF-7 cells and causes S phase cell cycle arrest, e... | |||
T79727 | EGFR/CDK2-IN-2 | EGFR | |
EGFR/CDK2-IN-2 (compound 6a) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 19.6 nM and 87.9 nM, respectively. It promotes apoptosis in MCF-7 cells and halts cell cycle progression du... | |||
T39943 | CDK7-IN-6 | CDK7-IN-6 | |
CDK7-IN-6 is a highly effective and specific inhibitor (IC50 ≤100 nM) of cyclin-dependent kinase 7 (CDK7). It showcases remarkable selectivity, with more than a 200-fold preference for CDK7 over CDK1, CDK2, and CDK5. Thi... | |||
T79728 | EGFR/CDK2-IN-3 | EGFR | |
EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively. It prompts apoptosis in MCF-7 cells and halts the cell cycle in the S p... | |||
T73163 | CDK7-IN-20 | ||
CDK7-IN-20 is a potent, selective, and irreversible inhibitor of Cyclin-Dependent Kinase 7 (CDK7) with an IC50 value of 4 nM, exhibiting over 206-fold selectivity against related kinases CDK1, CDK2, CDK3, CDK5, CDK6, CDK... | |||
T81739 | Multi-target kinase inhibitor 2 | EGFR | |
Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 values between 40 to 204 nM. It exhibits cytotoxic effects on HepG2... | |||
T78792 | Multi-kinase-IN-4 | VEGFR | |
Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor active against VEGFR2, EGFR, HER2, and CDK2, with respective IC50 values of 0.33, 0.22, 0.18, and 2.09 μM. It exhibits broad-spectrum anti-cancer prope... | |||
T79370 | FD2056 | PI3K | |
FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. Additionally, it exhibits inhibitory effects on CDK2-CyclinA2 and ... |