c1s — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T74816	Complement C1s-IN-1
	Complement C1s-IN-1 is a potent and selective C1s inhibitor that is orally active and capable of crossing the blood-brain barrier, demonstrating an IC50 value of 36 nM [1].
T10969	DC1SMe		Others
	DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer. DC1Sme is a DC1 derivative with IC50 ...		Others
T13568L	BCX 1470 hydrochloride	BCX 1470 hydrochloride(217099-43-9 Free base),BCX1470 HCl	Serine Protease , Complement System
	BCX 1470 hydrochloride is a potent serine protease inhibitor with anti-inflammatory activity that inhibits the ester hydrolysis and haemolytic activity of factor D and C1s, and can be used to study oedema.		Serine Protease , Complement System
T13568	BCX 1470		Serine Protease
	BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.		Serine Protease
T13567	BCX 1470 methanesulfonate		Serine Protease
	BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.		Serine Protease

Compounds

Complement C1s-IN-1

T74816

BCX 1470 hydrochloride

T13568L

Synonym: BCX 1470 hydrochloride(217099-43-9 Free base),BCX1470 HCl

Target: Serine Protease, Complement System

BCX 1470

T13568

Synonym:

Target: Serine Protease

BCX 1470 methanesulfonate

T13567

Synonym:

Target: Serine Protease

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-06585	C1s Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex comp...
TMPY-00359	C1s-A subcomponent Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	C1s-A subcomponent Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 76.6 kDa and the accession number is AAH18319.1.
TMPH-02603	C1SB Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
TMPK-01051	BLOC1S2 Protein, Human, Recombinant	Human	E. coli
	BLOC1S2 (Biogenesis of lysosome-related organelles complex-1 subunit 2) protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of t...
TMPY-02980	BLOC1S2 Protein, Human, Recombinant (GST)	Human	E. coli
	BLOC1S2, also known as BLOS2, belongs to the BLOC1S2 family. It is a component of BLOC-1 complex. The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. The BLOC-1 co...
TMPH-02596	C1QA Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and effi...
TMPH-02602	C1RA Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
TMPH-02597	C1QA Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and effi...
TMPH-03272	Complement factor D Protein, Rat, Recombinant (His)	Rat	P. pastoris (Yeast)
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi...
TMPH-03271	Complement factor D Protein, Rat, Recombinant (His & Myc)	Rat	HEK293 Cells
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi...
TMPY-04137	ATP6V1F Protein, Human, Recombinant (GST)	Human	E. coli
	ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using revers...
TMPY-01712	C1QB Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulon...
TMPJ-01064	Serpin G1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement sy...
TMPJ-00980	Complement Factor MASP3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway. The MBL pathway is initiated by the binding of MBL to specific carbohydrate structures found on the surface of a variety of micro...
TMPY-01692	NETO1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR...