Search Result

Search Results for " arginase "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T76208	Arginase
	Arginase is an enzyme of the urea cycle. Arginase catalyzes the hydrolysis of L-arginine to L-ornithine and urea [1] .
T10367	Arginase inhibitor 1		Others
	Arginase inhibitor 1 is a potent inhibitor of human arginases I and II (IC50s: 223 and 509 nM).		Others
T6779	BEC hydrochloride	BEC HCl	Arginase
	BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II, and is 0.4-0.6 μM for rat Arginase I.		Arginase
T12240	Nor-NOHA acetate	Nω-Hydroxy-nor-L-arginine acetate	Apoptosis , Arginase
	nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a reversible inhibitor of arginase, with anti-leukemic activity, effective in endothelial dysfunction, immunosuppression, and metabolism.		Apoptosis , Arginase
T9096	Nω-Hydroxy-nor-L-Arginine Dihydrochloride		Arginase
	Nω-Hydroxy-nor-L-Arginine Dihydrochloride is a competitive and reversible inhibitor of arginase		Arginase
T39766	Nor-NOHA monoacetate	Nor NOHA monoacetate,Nω-Hydroxy-nor-L-arginine monoacetate	Arginase
	nor-NOHA monoacetate (Nω-Hydroxy-nor-L-arginine) is a highly potent and selective arginase inhibitor. nor-NOHA monoacetate inhibits rat hepatic arginase and inhibits the hydrolysis of L-arginine, which can be used to stu...		Arginase
T12206	NED-3238		Others
	NED-3238 is a highly potent inhibitor of arginase I and II (IC50 of 1.3 nM and 8.1 nM, respectively).		Others
T10692	CB-1158 dihydrochloride (2095732-06-0 free base)	INCB01158 dihydrochloride,CB-1158 dihydrochloride	Others
	CB-1158 dihydrochloride is an effective and orally active inhibitor of arginase (IC50s: 86 nM and 296 nM for recombinant human arginase 1 and 2).		Others
T10692L	Numidargistat	INCB01158,CB-1158	Others
	CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2).		Others
T61336	Numidargistat dihydrochloride
	Numidargistat dihydrochloride (CB-1158) is a highly potent and orally active chemical compound that effectively inhibits arginase. It exhibits IC50 values of 86 nM and 296 nM for recombinant human arginase 1 and 2, respe...
T26516	ABH Hydrochloride	6-borono-L-norleucine,ABH HCl
	ABH Hydrochloride is an arginase inhibitor, it enhances both male and female sexual arousal responses.
T39932	ARG1-IN-1	ARG1-IN-1
	ARG1-IN-1 is a human arginase 1 inhibitor with an IC 50 of 29 nM.
T70367	SNU-BP
	SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polari...
T78656	ARG1-IN-1 hydrochloride		Arginase
	ARG1-IN-1 hydrochloride is a potent inhibitor of human arginase 1, exhibiting an IC50 value of 29 nM [1].		Arginase
T70928	CB-1158-analog
	CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vi...
T83779	EP4 Antagonist 14	Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
	EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A...

Compounds

Arginase inhibitor 1

Synonym: Nω-Hydroxy-nor-L-arginine acetate

Target: Apoptosis, Arginase

Nω-Hydroxy-nor-L-Arginine Dihydrochloride

Synonym: Nor NOHA monoacetate,Nω-Hydroxy-nor-L-arginine monoacetate

CB-1158 dihydrochloride (2095732-06-0 free base)

T10692

Synonym: INCB01158 dihydrochloride,CB-1158 dihydrochloride

Target: Others

Numidargistat

T10692L

Synonym: INCB01158,CB-1158

Target: Others

Numidargistat dihydrochloride

Synonym: 6-borono-L-norleucine,ABH HCl

ARG1-IN-1 hydrochloride

Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

Target:

Cat No.	Product Name	Synonyms	Targets
T11054	DL-Norvaline	2-Aminopentanoic acid	Arginase , Endogenous Metabolite
	DL-Norvaline (2-Aminopentanoic acid) is a non-competitive inhibitor of arginase.		Arginase , Endogenous Metabolite
T3S0401	Piceatannol 3'-O-glucoside	Piceatannol 3-glycoside,Quzhaqigan	Arginase , NO Synthase
	Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury.		Arginase , NO Synthase
T4788	L-Norvaline		Others , Endogenous Metabolite
	L-Norvaline is an arginase inhibitor and a non-proteinogenic branched-chain amino acid. L-Norvaline has previously been reported to be a natural component of an antifungal peptide of Bacillus subtilis. L-Norvaline and ot...		Others , Endogenous Metabolite
T38241	2-Aminoimidazole
	2-Aminoimidazole is a potent antibiofilm agent and adjuvant to antimicrobial treatments, which effectively disrupts bacterial self-protection mechanisms by inhibiting biofilm formation and genetically-encoded antibiotic ...
TN6456	N-trans-caffeoyloctopamine
	N-trans-Caffeoyltyramine has both arginase inhibitory property and antioxidant capacity.
T11802	L-Canaline		Others
	L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50...		Others

Natural Products

DL-Norvaline

T11054

Synonym: 2-Aminopentanoic acid

Target: Arginase, Endogenous Metabolite

Piceatannol 3'-O-glucoside

T3S0401

Synonym: Piceatannol 3-glycoside,Quzhaqigan

Target: Arginase, NO Synthase

L-Norvaline

T4788

Synonym:

Target: Others, Endogenous Metabolite

N-trans-caffeoyloctopamine

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02168	Arginase 1/ARG1 Protein, Human, Recombinant (His)	Human	HEK293
	Arginase is the focal enzyme of the urea cycle hydrolysing L-arginine to urea and L-ornithine. Emerging studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxid...
TMPH-02526	Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synth...
TMPH-02524	Arginase-1/ARG1 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ...
TMPH-02525	Arginase-1/ARG1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ...
TMPY-04685	Arginase 1/ARG1 Protein, Human, Recombinant (His & MYC)	Human	HEK293
	Arginase is the focal enzyme of the urea cycle hydrolysing L-arginine to urea and L-ornithine. Emerging studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxid...
TMPJ-01058	ARG2 Protein, Human, Recombinant (His)	Human	E. coli
	Arginase-2 (ARG2) is a member of the arginase family. Arginase is a manganese-containing enzyme which catalyzes the hydrolysis of arginine to ornithine and urea. ARG2 is highly expressed in kidney and prostate, not found...