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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9809 | E3 ligase Ligand 23 | Ligand for E3 Ligase | |
E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome. | |||
T60024 | CFT7455 | Cemsidomide | Ligand for E3 Ligase |
CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZ... | |||
T73463 | NX-2127 | NX2127,NX 2127 | BTK |
NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 ... | |||
T26688 | Avadomide HCl | Avadomide hydrochloride,CC122, Avadomide HCl,CC-122,CC 122 HCl | |
Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes de... | |||
T63024 | (Rac)-CFT7455 | ||
(Rac)-CFT7455 is an Ikaros/Aiolos degradation agent that acts via the ubiquitin proteasome pathway and is able to act on NCIH929.1 cells (GI50: 0.05 nM). (Rac)-CFT7455 is a racemic isomer of CFT7455 and has anticancer ac... | |||
T63771 | CC-99282 | ||
CC-99282 is a potent, orally active CRBN E3 ligase modulator (CELMoD).CC-99282 acts in combination with CRBN to co-induce effective and targeted degradation of Ikaros and Aiolos.CC-99282 can be used to study non-Hodgkin'... |