atx — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10410	ATX inhibitor 1		PDE
	ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).		PDE
T10409	ATX inhibitor 5		PDE
	ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,.		PDE
T39190	ATX-002
	ATX-002 is a property-tunable lipid for RNA drug delivery.
T39136	ATX inhibitor 7
	ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure.
T80039	ATX-II		Sodium Channel
	ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pulmonary vein arrhythmogenesis and atrial fibrillation [1] [...		Sodium Channel
T61612	ATX inhibitor 15
	ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activ...
T64141	ATX inhibitor 11
	ATX inhibitor 11 is a potent inhibitor of ATX (autotaxin) (IC50: 2.7 nM). ATX inhibitor 11 alleviates the severity of fibrotic tissue and effectively reduces the deposition of α-SMA, a biomarker of fibrosis, in a mouse m...
T63325	ATX inhibitor 9
	ATX inhibitor 9 is a thickened heteroaryl derivative compound and a potent inhibitor of ATX. Among them Autotaxin (ATX), also known as ENPP2, is a secreted enzyme highly expressed mainly in lung cancer cells, bronchial e...
T82936	ATX-II TFA		Sodium Channel
	ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the sea anemone (Anemonia sulcata). This compound impedes the inactivation of Na+ channels and has been associated with arrhythmogenesis in...		Sodium Channel
T63904	ATX inhibitor 19
	ATX inhibitor 19 is a potent inhibitor of ATX (IC50: 156 nM).
T72681	ATX inhibitor 17
	ATX inhibitor 17, a powerful ATX inhibitor, exhibits an IC50 value of 0.019 µM, demonstrating significant anti-proliferative effects in breast cancer cells.
T64210	ATX inhibitor 13
	ATX inhibitor 13 (compound 10c) is an orally active ATX inhibitor (IC50: 3.4 nM). ATX inhibitor 13 is capable of blocking the cell cycle of RAW264.7 cells in the G2 phase, inhibiting cell proliferation and migration and ...
T63584	ATX inhibitor 12
	ATX inhibitor 12 is an orally active ATX inhibitor (IC50: 1.72 nM). In C57Bl/6J mice, oral administration of ATX inhibitor 12 at a dose of 60 mg/kg was effective in inhibiting structural lung damage and reducing fibrotic...
T63845	ATX inhibitor 14
	ATX inhibitor 14, an indole-based carbamate derivative, is a potent inhibitor (IC50: 0.41 nM) of self-adhesive proteins (ATX) and has shown potential for research in fibrosis-related diseases.
T27324	FK614	FK 614,ATx-08-001,ATx-08001,FK-614
	FK-614 is a selective agonist of peroxisome proliferator-activated receptor gamma. FK-614 improves peripheral glucose utilization while decreases hepatic insulin extraction in alloxan-induced diabetic dogs.
T63510	ATX inhibitor 21
	ATX inhibitor 21 is a potent inhibitor of ATX (IC50: 3490 nM).
T63829	ATX inhibitor 20
	ATX inhibitor 20 is a potent inhibitor of ATX (IC50: 2.3 nM).
T63524	ATX inhibitor 10
	ATX inhibitor 10 is a nitrogen-containing heterocyclic compound that is a potent inhibitor of ATX. Among other things, ATX plays a role in causing pathologies including fibrosis, neurodegeneration, arthritis, neuropathic...
T63612	ATX inhibitor 8
	ATX inhibitor 8 is an inhibitor of the autocrine motor factor Autotaxin (ATX).
T64130	ATX inhibitor 16
	ATX inhibitor 16 is a potent inhibitor of ATX (IC50: 0.0021 μM). ATX inhibitor 16 exhibits a significant anti-proliferative effect on breast cancer cells.