alk5 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3031	A 83-01	ALK5 Inhibitor IV,A8301	ALK , TGF-beta/Smad
	A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cult...		ALK , TGF-beta/Smad
T2109	SD-208	ALK5 Inhibitor V,SD208	TGF-beta/Smad
	SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.		TGF-beta/Smad
T6337	RepSox	ALK5 Inhibitor II,SJN 2511,E-616452	ALK , TGF-beta/Smad
	RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.		ALK , TGF-beta/Smad
T22560	ALK5 Inhibitor II (hydrochloride)		Others
	ALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively.		Others
T62614	ALK5-IN-29
	ALK5-IN-29 is a selective inhibitor of activin receptor-like kinase (ALK).ALK5-IN-29 inhibits activin receptor-like kinase activity (IC50 ≤ 10 nM).AALK5-IN-29 inhibits tumour growth and can be used in the study of prolif...
T62116	ALK5-IN-33
	ALK5-IN-33 (Compound EX-10) is an orally active, selective inhibitor of ALK-5 (IC50 ≤ 10 nM).
T62302	ALK5-IN-28
	ALK5-IN-28 is a selective inhibitor of ALK-5 with an IC50 ≤ 10 nM that inhibits TGF-β-induced SMAD signalling.ALK5-IN-28 has the potential to inhibit tumour growth in vivo.ALK5-IN-28 can be used to study proliferative di...
T62394	ALK5-IN-31
	ALK5-IN-31 is a selective inhibitor of ALK-5 (IC50≤10 nM) and also inhibits TGF-β-induced SMAD signalling.ALK5-IN-31 has the potential to inhibit tumour growth in vivo.ALK5-IN-31 can be used in the study of proliferative...
T62546	ALK5-IN-27
	ALK5-IN-27 (Compound EX-04) is a potent inhibitor of ALK-5 (IC50 ≤ 10 nM). ALK5-IN-27 also inhibits ALK-2.
T62615	ALK5-IN-30
	ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).
T62393	ALK5-IN-25
	ALK5-IN-25 (compound EX-02) is a potent inhibitor of ALK-5 (IC50<10 nM) and also inhibits ALK-2. ALK5-IN-25 can be used in cancer research.
T63498	ALK5-IN-6
	ALK5-IN-6 is a potent inhibitor of ALK5. ALK5-IN-6 has potential for TGF-β-related diseases and conditions, including but not limited to tumors, inflammatory diseases, fibrotic diseases, autoimmune diseases, etc.Among th...
T62613	ALK5-IN-26
	ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).
T64051	ALK5-IN-9
	ALK5-IN-9 is a potent, orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation (IC50: 25 nM) and inhibits NIH3T3 cell activity (IC50: 74.6 nM). ALK5-IN-9 has shown research potential in canc...
T61203	ALK5-IN-8
	ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently...
T63114	ALK5-IN-7
	ALK5-IN-7 is an effective inhibitor of ALK5. Transforming growth factor β (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation, and apoptosis through autocrine, paracri...
T62117	ALK5-IN-34
	ALK5-IN-34 is a selective, orally active inhibitor of activin receptor-like kinase (ALK), which inhibits the activity of activin receptor-like kinase (IC50 ≤ 10 nM) and also inhibits tumour growth.
T62395	ALK5-IN-32
	ALK5-IN-32 is a selective inhibitor of ALK-5 (10 nM50<100 nM) and also inhibits TGF-β-induced SMAD signaling.ALK5-IN-31 has the potential to inhibit tumor growth in vivo.ALK5-IN-31 can be used in the study of prolifer...
T5125	LY3200882		TGF-beta/Smad
	LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).		TGF-beta/Smad
T8330	BIO-013077-01		TGF-beta/Smad
	BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.		TGF-beta/Smad