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Search Results for " alk-in-5 "

11

Compounds

Cat No. Product Name Synonyms Targets
T10283 ALK-IN-5 ALK
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T3678 Entrectinib RXDX-101,NMS-E628 Trk receptor , ROS , ALK , Autophagy , ROS Kinase
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini...
T68537 CEP-14513
CEP-14513 is a potent ALK inhibitor. CEP-14513 displayed potent ALK inhibitory activity in both in vitro enzymatic assay (IC50 = 5 nM) and cell-based assays of ALK tyrosine phosphorylation (IC50 = 30 nM).
T62546 ALK5-IN-27
ALK5-IN-27 (Compound EX-04) is a potent inhibitor of ALK-5 (IC50 ≤ 10 nM). ALK5-IN-27 also inhibits ALK-2.
T62116 ALK5-IN-33
ALK5-IN-33 (Compound EX-10) is an orally active, selective inhibitor of ALK-5 (IC50 ≤ 10 nM).
T61443 Trk-IN-7
Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (...
T62393 ALK5-IN-25
ALK5-IN-25 (compound EX-02) is a potent inhibitor of ALK-5 (IC50<10 nM) and also inhibits ALK-2. ALK5-IN-25 can be used in cancer research.
T13139 TP-008 TGFβRI-IN-2 Others
TGFβRI-IN-2 is a selective, potent and orally active inhibitor of (Activin-Like Kinase 5) ALK 5(pIC50 and pEC50 values of 7.6 and 6.63, respectively).
T62394 ALK5-IN-31
ALK5-IN-31 is a selective inhibitor of ALK-5 (IC50≤10 nM) and also inhibits TGF-β-induced SMAD signalling.ALK5-IN-31 has the potential to inhibit tumour growth in vivo.ALK5-IN-31 can be used in the study of proliferative...
T62302 ALK5-IN-28
ALK5-IN-28 is a selective inhibitor of ALK-5 with an IC50 ≤ 10 nM that inhibits TGF-β-induced SMAD signalling.ALK5-IN-28 has the potential to inhibit tumour growth in vivo.ALK5-IN-28 can be used to study proliferative di...
T62395 ALK5-IN-32
ALK5-IN-32 is a selective inhibitor of ALK-5 (10 nM50<100 nM) and also inhibits TGF-β-induced SMAD signaling.ALK5-IN-31 has the potential to inhibit tumor growth in vivo.ALK5-IN-31 can be used in the study of prolifer...
TargetMol