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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10287 | ALK2-IN-2 | ALK , TGF-beta/Smad | |
ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3. | |||
T39764 | ALK2-IN-4 | ALK2-IN-4 | |
ALK2-IN-4, a highly effective ALK2 inhibitor. | |||
T79393 | ALK/EGFR-IN-2 | ||
ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells. It effectively suppresses proliferation in H1975, PC9, and Baf3-EML4-ALK cancer cell lines... | |||
T40065 | ALK2-IN-4 succinate | ALK2-IN-4 succinate | |
ALK2-IN-4 succinate is a robust and effective inhibitor of ALK2. | |||
T3059 | ALK-IN-1 | AP26113,Brigatinib,AP26113-analog | EGFR , IGF-1R , ALK |
ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2. | |||
T62546 | ALK5-IN-27 | ||
ALK5-IN-27 (Compound EX-04) is a potent inhibitor of ALK-5 (IC50 ≤ 10 nM). ALK5-IN-27 also inhibits ALK-2. | |||
T62393 | ALK5-IN-25 | ||
ALK5-IN-25 (compound EX-02) is a potent inhibitor of ALK-5 (IC50<10 nM) and also inhibits ALK-2. ALK5-IN-25 can be used in cancer research. | |||
T13139 | TP-008 | TGFβRI-IN-2 | Others |
TGFβRI-IN-2 is a selective, potent and orally active inhibitor of (Activin-Like Kinase 5) ALK 5(pIC50 and pEC50 values of 7.6 and 6.63, respectively). |