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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6614 | Nutlin-3b | (+)-Nutlin-3 | Mdm2 , E1/E2/E3 Enzyme |
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. | |||
T6023 | Nutlin-3a | (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3 | Apoptosis , E1/E2/E3 Enzyme , Autophagy |
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein. | |||
T2158 | Nutlin-3 | Nutlin3 | E1/E2/E3 Enzyme |
Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells. |