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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T61211 | 5-LOX-IN-1 | Lipoxygenase | |
5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research. | |||
T60630 | COX/5-LOX-IN-1 | ||
COX/5-LOX-IN-1 (compound 6b) is a potent COX/5-LOX dual inhibitor with the potential for inflammation diseases research. COX/5-LOX-IN-1 has IC50s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectivel... | |||
T61674 | COX-2/5-LOX-IN-1 | ||
COX-2/5-LOX-IN-1 (compound 3a), a benzothiophen-2-yl pyrazole carboxylic acid derivative, is a potent and dual inhibitor of COX-2 / 5-LOX. It exhibits superior analgesic and anti-inflammatory properties compared to Celec... | |||
T21838 | 1-Naphthyl 3,5-dinitrobenzoate | JMC-4 | Lipoxygenase |
1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy. | |||
T6S0413 | Pectolinarigenin | Pectolinaringenin | Others , Lipoxygenase , COX |
1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ... | |||
T61352 | COX-2/5-LOX-IN-3 | ||
COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows pro... | |||
T61910 | COX-2/5-LOX-IN-2 | ||
COX-2/5-LOX-IN-2 is a benzothiophen-2-ylpyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 (5b) inhibited both COX-2 and 5-LOX. The IC50s of COX-2/5-LOX-IN-2 inhibiting COX-1, COX-2 and 5-LOX were 5.40, 0.01 and 1.78 ... | |||
T78820 | 5-LOX-IN-5 | Lipoxygenase | |
Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in research pertaining to neurodegenerative diseases [1]. | |||
T22172 | YS-121 | ||
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 ( mPGES-1; IC 50 =3.4 μM) and 5-lipoxygenase ( 5-LOX; IC 50 =6.5 μM). YS121 dose-dependently reduces the production of PGE2 with EC 50 =12 μM in IL-1β-s... | |||
T81181 | SEH/FLAP-IN-1 | FLAP | |
sEH/FLAP-IN-1 (Compound 46A) serves as a dual inhibitor targeting both sEH and FLAP. It effectively suppresses 5-LOX product formation with an EC50 of 11 nM in SACM-stimulated PBMCs and also inhibits sEH activity (EC50: ... | |||
T78705 | COX-2-IN-30 | COX | |
COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). ... | |||
T78706 | COX-2-IN-31 | COX | |
COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Additionally, it inhibits the activity of transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM). This... | |||
T37805 | JKE-1716 | ||
JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additi... |