The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (IGF-1 and IGF-2), a family of seven high-affinity IGF-binding proteins (IGFBP1 to IGFBP7), as well as associated IGFBP degrading enzymes, referred to collectively as proteases. The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (IGF-1) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer. The IGF axis has been shown to play roles in the promotion of cell proliferation and the inhibition of cell death.
Cat No. | product name / Synonyms | Species | Expression System |
---|---|---|---|
TMPY-02295 | IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc)
IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc)
|
Human | HEK293 Cells |
IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.5 kDa and the acces... | |||
TMPY-06982 | IGF1/IGF-I Protein, Human, Recombinant
IGF1/IGF-I Protein, Human, Recombinant
|
Human | E. coli |
IGF1/IGF-I Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.8 KDa. and the accession number is P05019-1... | |||
TMPY-06982 | IGF1/IGF-I Protein, Human, Recombinant
IGF1/IGF-I Protein, Human, Recombinant
|
Human | E. coli |
IGF1/IGF-I Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.8 KDa. and the accession number is P05019-1... | |||
TMPY-06982 | IGF1/IGF-I Protein, Human, Recombinant
IGF1/IGF-I Protein, Human, Recombinant
|
Human | E. coli |
IGF1/IGF-I Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.8 KDa. and the accession number is P05019-1... | |||
TMPY-06982 | IGF1/IGF-I Protein, Human, Recombinant
IGF1/IGF-I Protein, Human, Recombinant
|
Human | E. coli |
IGF1/IGF-I Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.8 KDa. and the accession number is P05019-1... | |||
TMPY-02533 | IGFBP-7 Protein, Human, Recombinant (aa 30-282, His)
IGFBP-7 Protein, Human, Recombinant (aa 30-282, His)
|
Human | HEK293 Cells |
IGFBP-7 Protein, Human, Recombinant (aa 30-282, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the acce... | |||
TMPY-00836 | IGFBP-4 Protein, Human, Recombinant (His)
IGFBP-4 Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
IGFBP-4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession numbe... | |||
TMPY-04508 | IGFBP-7 Protein, Mouse, Recombinant (aa 1-281, hFc)
IGFBP-7 Protein, Mouse, Recombinant (aa 1-281, hFc)
|
Mouse | HEK293 Cells |
IGFBP-7 Protein, Mouse, Recombinant (aa 1-281, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.3 kDa and the acces... |