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Fibroblast Growth Factor Receptors, FGFRs

The fibroblast growth factor receptors (FGFR) are receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. The fibroblast growth factor receptors consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. The FGF/FGFR signalling pathway is involved in a variety of cancers.There are non-selective FGFR inhibitors that act on all of FGFR1-4 and other proteins, and some selective FGFR inhibitors for some/all of FGFR1-4. Selective FGFR inhibitors include AZD4547, BGJ398, JNJ42756493, and PD173074.

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Species
Cynomolgus (3)
Human (50)
Mouse (11)
Rat (2)
Rhesus (6)
Expression System
Baculovirus Insect Cells (3)
HEK293 Cells (68)
Tag
C-6xHis (1)
C-Avi (2)
C-His (24)
C-His-Avi (21)
C-hFc (17)
GST (3)
His (6)
hFc (3)
Cat No. product name / Synonyms Species Expression System
TMPK-00395 FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weigh...
TMPK-00396 FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weigh...
TMPK-00397 FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight...
TMPK-00398 FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)
Human HEK293 Cells
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and...
TMPK-00399 FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated
Human HEK293 Cells
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is...
TMPK-00400 FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight...
TMPK-00401 FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, t...
TMPK-00475 FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His)
FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293 Cells
FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.2 kDa and th...
TMPK-00686 FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His)
FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.09 kDa and the a...
TMPK-00847 FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His)
FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.3 kDa and the acc...
TMPK-01322 FGFR4 Protein, Rhesus macaque, Recombinant (His)
FGFR4 Protein, Rhesus macaque, Recombinant (His)
Rhesus HEK293 Cells
FGFR4 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.66 kDa and the acces...
TMPY-00257 FGFR3 Protein, Cynomolgus, Rhesus, Recombinant (His)
FGFR3 Protein, Cynomolgus, Rhesus, Recombinant (His)
Cynomolgus,Rhesus HEK293 Cells
FGFR3 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the acce...
TMPY-00351 FGFR2 Protein, Human, Recombinant (beta IIIc, His)
FGFR2 Protein, Human, Recombinant (beta IIIc, His)
Human HEK293 Cells
FGFR2 Protein, Human, Recombinant (beta IIIc, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.2 kDa and the access...
TMPY-00389 FGFR3 Protein, Human, Recombinant (alpha IIIb, hFc)
FGFR3 Protein, Human, Recombinant (alpha IIIb, hFc)
Human HEK293 Cells
FGFR3 Protein, Human, Recombinant (alpha IIIb, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.3 kDa and the acces...
TMPY-00806 FGFR4 Protein, Human, Recombinant (hFc)
FGFR4 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
FGFR4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66 kDa and the accession number is...
TMPY-00973 FGFR3 Protein, Mouse, Recombinant (His & hFc)
FGFR3 Protein, Mouse, Recombinant (His & hFc)
Mouse HEK293 Cells
FGFR3 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 66 kDa and the acces...
TMPY-00974 FGFR4 Protein, Mouse, Recombinant (His)
FGFR4 Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
FGFR4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is...
TMPY-01019 FGFR4 Protein, Mouse, Recombinant (His & hFc)
FGFR4 Protein, Mouse, Recombinant (His & hFc)
Mouse HEK293 Cells
FGFR4 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67 kDa and the acces...
TMPY-01208 FGFR3 Protein, Mouse, Recombinant (His)
FGFR3 Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
FGFR3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is...
TMPY-01228 FGFR2 Protein, Human, Recombinant (aa 1-377, His)
FGFR2 Protein, Human, Recombinant (aa 1-377, His)
Human HEK293 Cells
FGFR2 Protein, Human, Recombinant (aa 1-377, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41 kDa and the accession...
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00395
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weigh...
FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00396
FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weigh...
FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00397
FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight...
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)
TMPK-00398
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and...
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated
TMPK-00399
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is...
FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00400
FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight...
FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00401
Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, t...
FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His)
TMPK-00475
FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.2 kDa and th...
FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His)
TMPK-00686
FGFR3 alpha (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 37.09 kDa and the a...
FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His)
TMPK-00847
FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.3 kDa and the acc...
FGFR4 Protein, Rhesus macaque, Recombinant (His)
TMPK-01322
FGFR4 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.66 kDa and the acces...
FGFR3 Protein, Cynomolgus, Rhesus, Recombinant (His)
TMPY-00257
FGFR3 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the acce...
FGFR2 Protein, Human, Recombinant (beta IIIc, His)
TMPY-00351
FGFR2 Protein, Human, Recombinant (beta IIIc, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.2 kDa and the access...
FGFR3 Protein, Human, Recombinant (alpha IIIb, hFc)
TMPY-00389
FGFR3 Protein, Human, Recombinant (alpha IIIb, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.3 kDa and the acces...
FGFR4 Protein, Human, Recombinant (hFc)
TMPY-00806
FGFR4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66 kDa and the accession number is...
FGFR3 Protein, Mouse, Recombinant (His & hFc)
TMPY-00973
FGFR3 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 66 kDa and the acces...
FGFR4 Protein, Mouse, Recombinant (His)
TMPY-00974
FGFR4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is...
FGFR4 Protein, Mouse, Recombinant (His & hFc)
TMPY-01019
FGFR4 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67 kDa and the acces...
FGFR3 Protein, Mouse, Recombinant (His)
TMPY-01208
FGFR3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is...
FGFR2 Protein, Human, Recombinant (aa 1-377, His)
TMPY-01228
FGFR2 Protein, Human, Recombinant (aa 1-377, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41 kDa and the accession...
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TargetMol