Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | Inquiry | Inquiry | |
500 mg | Inquiry | Inquiry |
Description | TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation. |
Targets&IC50 | BRD4:0.32 nM (Dc50), cereblon: |
In vitro | TD-428 comprises TD-106 linked to a BET inhibitor, JQ1 efficiently induce BET protein degradation in the prostate cancer cell line 22Rv1. the proliferation of 22RV1 cells(CC50?of??20.1?nM) inhibited by TD-428. TD-428 (1 nM-10?μM; 12?hours) induces the degradation of BRD4, IKZF1, and IKZF3 proteins. |
Molecular Weight | 879.38 |
Formula | C43H43ClN10O7S |
CAS No. | T13105 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TD-428 T13105 Chromatin/Epigenetic Epigenetic Reader Domain TD428 TD 428 inhibitor inhibit