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Search Result

Search Results for " cyp51 "

24

Compounds

2

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T64154 CYP51/HDAC-IN-1
CYP51/HDAC-IN-1 is an orally active, potent, dual CYP51/HDAC inhibitor that inhibits important virulence factors and down-regulates the expression of associated drug resistance genes.CYP51/HDAC-IN-1 has shown effective t...
T78902 CYP51/PD-L1-IN-4
CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51/PD-L1, displaying IC50 values of 0.17 and 0.021 μM, respectively. This compound demonstrates significant antifungal efficacy and combats drug-r...
T79740 CYP51/PD-L1-IN-3
CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM). This compound promotes early fungal apoptosis within the ...
T79738 CYP51/PD-L1-IN-1
CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM). This compound prompts early apoptosis in the fungal cell cycle, marked...
T79739 CYP51/PD-L1-IN-2
CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM). The compound promotes early apoptosis in the fungal ...
T4188 SDZ285428 SDZ285-428 P450 , Parasite , Antifungal
SDZ285428 is a CYP24A1 inhibitor.
T17022 Tebuconazole P450 , Antifungal
Tebuconazole is an agricultural azole fungicide. It can also inhibit CYP51 (IC50s: 0.9 and 1.3 μM for Candida albicans CYP51 and truncated Homo sapiens CYP51, respectively).
T16412 Oteseconazole VT-1161 P450 , Antifungal
Oteseconazole (VT-1161) is an orally active anti-fungal agent. Oteseconazole displays no obvious effect on human CYP51. It also potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM).
T16704L Quilseconazole Formic acid(1340593-70-5 Free base) Quilseconazole Formic acid(1340593-70-5 Free base) Antifungal
Quilseconazole Formic acid is a selective inhibitor of fungal Cyp51 with potent activities against Cryptococcus neoformans and Cryptococcus gattii.
T11991 Mefentrifluconazole P450 , Antifungal
Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and ...
T3934 Isavuconazonium sulfate Antifungal
Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh...
T16704 Quilseconazole VT-1129 Others
Quilseconazole is an effective, orally active fungal Cyp51 inhibitor. it also binds tightly to cryptococcal CYP51 but weakly inhibits humans CYP450 enzymes.
T63285 Antifungal agent 40
Antifungal agent 40 is an antifungal agent that extends into the narrow hydrophobic pocket II of C. alb. CYP51 and inhibits the activity of lanosterol 14α-demethylase (CYP51), which has an inhibitory effect on biofilm fo...
T72660 VT-1598 tosylate
VT-1598 tosylate is a selective, orally active antifungal compound that targets CYP51. It demonstrates efficacy against C. auris.
T27851 LP8 LP 8,LP-8
LP8 is a novel inhibitor of Trypanosoma cruzi CYP51.
T28739 SDZ-285604 SDZ285604,VNF,SDZ 285604
SDZ-285604 is a novel sterol 14a-demethylases (CYP51) inhibitor.
T70158 Quilseconazole besylate
Quilseconazole besylate, also known as VT-1129 besylate, is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor.
T79550 Antifungal agent 68
Antifungal agent 68 (compound 10) effectively combats fungal infections caused by Candida and Cryptococcus gattii through the inhibition of ergosterol biosynthesis, likely via interaction with lanosterol 14α-demethylase ...
T64127 VT-1598
VT-1598 is a novel, selective, orally active fungal CYP51 inhibitor. VT-1598 exhibits antifungal effects against Candida albicans.
T27848 LP10 LP-10,LP 10
LP10 is a reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1 and a Potent type II inhibitor of Trypanosoma cruzi CYP51.
T64029 Antifungal agent 42
Antifungal agent 42 is an antifungal agent that has an inhibitory effect on biofilm formation. Antifungal agent 42 inhibits C.alb.'s lanosterol 14α-demethylase (CYP51).
T75176 Antifungal agent 53
Antifungal Agent 53 (A03), a potent Candida albicans CYP51 inhibitor, exhibits antifungal activity by preventing fungi biofilm formation and demonstrates good safety [1].
T62635 Antifungal agent 30
Antifungal agent 30 is a potent antifungal agent that exhibits good antifungal activity against Candida albicans (CPCC400616) (MIC: 0.03 μg/mL) and Aspergillus fumigatus (MIC: 0.5 μg/mL). Antifungal agent 30 exerts antif...
T62211 Antifungal agent 33
Antifungal agent 33 (compound 4e) is a potent antifungal agent with significant antifungal activity against Candida albicans (MIC: 16 μg/ml). (IC50: 0.19 μg/ml).
Cat No. Product Name Synonyms Targets
TN6736 Dihydrolanosterol 24,25-Dihydrolanosterol,Lanostenol Others
Dihydrolanosterol (24,25-Dihydrolanosterol) is a sterol and the C24-25 hydrogenated products of lanosterol, dihydrolanosterol can be demethylated by mammal or yeast cytochrome P450 sterol 14alpha-demethylase
T12286 Obtusifoliol Others
Obtusifoliol is a specific inhibitor of CYP51(Trypanosoma brucei (TB) and human CYP51 with Kd values of 1.2 µM and 1.4 µM, respectively).

Natural Products

Dihydrolanosterol
TN6736
Synonym: 24,25-Dihydrolanosterol,Lanostenol
Target: Others
Obtusifoliol
T12286
Synonym:
Target: Others

Recombinant Proteins

Species：
Mycobacterium tuberculosis (1)
Expression System：
Baculovirus Insect Cells (1)
Tag：
N-10xHis, C-Myc (1)
Cat No. Product Name Species Expression System
TMPH-03017 CYP51 Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) Mycobacterium tuberculosis Baculovirus Insect Cells
Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethy...
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