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CRA-026440 hydrochloride

Catalog No. T10883L CAS 847459-98-7

Synonyms: CRA-026440 hydrochloride（847460-34-8 Free base）

CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM, respectively. CRA-026440 hydrochloride exhibits antitumor and antiangiogenic activities.

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CRA-026440 hydrochloride Chemical Structure

CRA-026440 hydrochloride, CAS 847459-98-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 146.00
5 mg	In stock	$ 372.00
10 mg	In stock	$ 556.00
25 mg	In stock	$ 896.00
50 mg	In stock	$ 1,220.00
100 mg	In stock	$ 1,650.00
500 mg	In stock	$ 3,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 439.00

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Purity: 99.78%

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Storage & Solubility Information

Description	CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM, respectively. CRA-026440 hydrochloride exhibits antitumor and antiangiogenic activities.
In vitro	CRA-026440 hydrochloride exhibits anti-proliferation effect on HUVEC endothelial cells with GI50 of 1.41 μM. CRA-026440 hydrochloride leads to the accumulation of acetylated histone and acetylated tubulin, thus inhibiting the growth of tumor cells and inducing cell apoptosis. CRA-026440 hydrochloride inhibits angiogenesis in vitro in a dose-dependent manner[1].
In vivo	CRA-026440 hydrochloride (100 mg/kg; intravenous injection; daily; three consecutive days) resulted in a significant decrease in tumor growth in mice carrying HCT116 or U937 human tumor xenografts[1].

Synonyms	CRA-026440 hydrochloride（847460-34-8 Free base）
Molecular Weight	456.92
Formula	C23H25ClN4O4
CAS No.	847459-98-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (109.43 mM)

References and Literature

1. Cao ZA, et al. CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. Mol Cancer Ther. 2006 Jul;5(7):1693-701.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Bioactive Compounds Library Max Chromatin Modification Compound Library Clinical Compound Library Histone Modification Compound Library DNA Damage & Repair Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CRA-026440 hydrochloride 847459-98-7 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC 847460-34-8 847460-34-8 Free base CRA-026440 Hydrochloride CRA 026440 Hydrochloride CRA026440 Hydrochloride CRA-026440 hydrochloride（847460-34-8 Free base） inhibitor inhibit

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