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ZLN024

Catalog No. T13411 CAS 723249-01-2

ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).

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ZLN024, CAS 723249-01-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 148.00
5 mg	In stock	$ 336.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,520.00
500 mg	In stock	$ 2,970.00
1 mL * 10 mM (in DMSO)	In stock	$ 341.00

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Purity: 99.82%

Biological Description

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Description	ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
Targets&IC50	AMPK α2β2γ1:0.13 μM (EC50), AMPK α1β1γ1:0.42 μM (EC50), AMPK α1β2γ1:1.1 µM, AMPK α2β1γ1:0.95 μM (EC50)
In vitro	ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312). ZLN024 increases the activity of α1β1γ1 by 1.5-fold and has an EC50 of 0.42 μM, and it increases the activity of α2β1γ1 by 1.7-fold with an EC50 of 0.95 μM. ZLN024 also directly activates recombinant AMPK α1β2γ1, by 1.7-fold with an EC50 of 1.1 μM; and AMPK α2β2γ1, by 1.6-fold with an EC50 of 0.13 μM.
In vivo	C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased.

Molecular Weight	325.22
Formula	C13H13BrN2OS
CAS No.	723249-01-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/ml (153.74 mM)

References and Literature

1. Zhang LN, et al. Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One. 2013 Aug 20;8(8):e72092.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Glycolysis Compound Library Anti-Diabetic Compound Library Epigenetics Compound Library Neuronal Differentiation Compound Library Antidepressant Compound Library Anti-Obesity Compound Library Pyroptosis Compound Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library

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Keywords

ZLN024 723249-01-2 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK Inhibitor AMP-activated protein kinase inhibit ZLN 024 ZLN-024 inhibitor

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