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WZB117

Catalog No. T7018   CAS 1223397-11-2

WZB117 is a Glucose Transporter 1 (GLUT1) inhibitor. when IC50 of WZB117 approximate 10 μM, it inhibits lung cancer A549 cells and breast cancer MCF7 cells proliferation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
WZB117 Chemical Structure
WZB117, CAS 1223397-11-2
Pack Size Availability Price/USD Quantity
5 mg In stock $ 43.00
10 mg In stock $ 70.00
25 mg In stock $ 143.00
50 mg In stock $ 235.00
100 mg In stock $ 348.00
200 mg In stock $ 518.00
500 mg In stock $ 832.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 99.54%
Purity: 99.39%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description WZB117 is a Glucose Transporter 1 (GLUT1) inhibitor. when IC50 of WZB117 approximate 10 μM, it inhibits lung cancer A549 cells and breast cancer MCF7 cells proliferation.
Targets&IC50 GLUT1:10μM
In vitro WZB117 treats Cancer cell resulting in decreases in levels of Glut1 protein, intracellular ATP, and glycolytic enzymes. And WZB117 inhibits glucose transport in human red blood cells. The declines in cyclin E2 as well as phosphorylated retinoblastoma and increases in ATP-sensing enzyme AMP-activated protein kinase (AMPK), lead to the cell-cycle arrest, senescence, and necrosis.
In vivo WZB117 inject 10 mg/kg daily intraperitoneal into nude mice, which were grafted human A549 lung cancer, show 70% reduction in tumor volume.
Kinase Assay Recombinant proteins expressed with Sf21 cells and baculovirus vectors are purified with affinity chromatography. JAK kinase assay is done by a homogeneous time-resolved fluorescence assay with the peptide substrate (-EQEDEPEGDYFEWLE). Each enzyme reaction is carried out with Ruxolitinib or control, JAK enzyme, 500 nM peptide, adenosine triphosphate (ATP; 1 mM), and 2% dimethyl sulfoxide (DMSO) for 1 hour. IC50 is the INCB018424 concentration required for inhibition of 50% of the fluorescent signal.
Cell Research Human non–small cell lung cancer (NSCLC) cell lines H1299 and A549 are treated with compound WZB117(10 μM) for 24 or 48 hours.
Animal Research Male NU/J nude mice were given intraperitoneal injection with WZB117 (10 mg/kg) daily for 10 weeks.
Molecular Weight 368.31
Formula C20H13FO6
CAS No. 1223397-11-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 36.8 mg/mL (100 mM)

Ethanol: 36.8 mg/mL (100 mM)

TargetMolReferences and Literature

1. Liu Y, et al. Mol Cancer Ther. 2012, 11(8):1672-1682. 2. Chen J, Wu D, Dong Z, et al. The expression and role of glycolysis-associated molecules in infantile hemangioma[J]. Life Sciences. 2020, 259: 118215.

TargetMolCitations

1. Chen X, Zhao Y, He C, et al. Identification of a novel GLUT1 inhibitor with in vitro and in vivo anti-tumor activity. International Journal of Biological Macromolecules. 2022, 216: 768-778. 2. Chen J, Wu D, Dong Z, et al. The expression and role of glycolysis-associated molecules in infantile hemangioma. Life Sciences. 2020, 259: 118215. 3. Liu Y, Hou Y, Zhang F, et al.ENO1 deletion potentiates ferroptosis and decreases glycolysis in colorectal cancer cells via AKT/STAT3 signaling.Experimental and Therapeutic Medicine.2024, 27(4): 1-9.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Metabolism Compound Library Anti-Cancer Metabolism Compound Library Bioactive Compound Library Glycolysis Compound Library Bioactive Compounds Library Max Glutamine Metabolism Compound Library Glycometabolism Compound Library Anti-Lung Cancer Compound Library Anti-Obesity Compound Library

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Keywords

WZB117 1223397-11-2 Metabolism transporter GLUT Inhibitor WZB-117 inhibit Glucose transporter WZB 117 inhibitor

 

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