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VU591 hydrochloride

Catalog No. T13320   CAS 1315380-70-1

VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590

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VU591 hydrochloride Chemical Structure
VU591 hydrochloride, CAS 1315380-70-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 148.00
5 mg In stock $ 372.00
10 mg In stock $ 549.00
25 mg In stock $ 869.00
50 mg In stock $ 1,170.00
100 mg In stock $ 1,580.00
500 mg In stock $ 3,170.00
1 mL * 10 mM (in DMSO) In stock $ 397.00
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Purity: 99.95%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590
Targets&IC50 ROMK:0.24 μM
Molecular Weight 404.76
Formula C16H13ClN6O5
CAS No. 1315380-70-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16 mg/mL (39.53 mM), sonification is recommended.

TargetMolReferences and Literature

1. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Bioactive Compound Library Inhibitor Library Potassium Channel Blocker Library NO PAINS Compound Library Ion Channel Inhibitor Library Anti-Cancer Compound Library

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Related compounds with same targets
Talatisamine Carvedilol phosphate hemihydrate Neosolaniol JNJ 303 Nifekalant hydrochloride Pimozide CLP290 Chenodeoxycholic acid

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Keywords

VU591 hydrochloride 1315380-70-1 Membrane transporter/Ion channel Potassium Channel VU 591 VU 591 Hydrochloride inhibit neurological Kir1.1 Inhibitor VU-591 Hydrochloride VU-591 hydrochloride VU591 KcsA ROMK channel ROMK Inhibitor VU-591 VU591 Hydrochloride inhibitor

 

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