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UK-371804

Catalog No. T3442 CAS 256477-09-5

Synonyms: UK371804

UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.

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UK-371804, CAS 256477-09-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 61.00
5 mg	In stock	$ 110.00
10 mg	In stock	$ 189.00
25 mg	In stock	$ 341.00
50 mg	In stock	$ 512.00
100 mg	In stock	$ 743.00
500 mg	In stock	$ 1,550.00
1 mL * 10 mM (in DMSO)	In stock	$ 119.00

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Purity: 99.26%

Purity: 95.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.
Targets&IC50	uPA:10 nM. (Ki)
In vitro	In the acute excision wound model in pigs, topical administration of UK-3718046 penetrates porcine wounds and inhibits exogenous uPA activity without adverse effects on wound-healing parameters.
In vivo	In vitro studies have shown that UK-3718046 is an inhibitor of exogenous uPA in human chronic wound fluid, displaying inhibitory capabilities with an IC50 of 0.89 μM.

Synonyms	UK371804
Molecular Weight	385.83
Formula	C14H16ClN5O4S
CAS No.	256477-09-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (25.92 mM), Sonification and heating are recommended.

References and Literature

1. Fish PV, et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Metabolism Disease Compound Library Preclinical Compound Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Protease Inhibitor Library Bioactive Compound Library Metabolism Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UK-371804 256477-09-5 Metabolism Proteases/Proteasome PAI-1 Serine Protease Inhibitor UK 371804 inhibit Plasminogen activator inhibitor-1 UK371804 inhibitor

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