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Catalog No. T2326   CAS 150683-30-0
Synonyms: OPC-41061

Tolvaptan is an orally bioavailable, selective, arginine Vasopressin Receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.

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Tolvaptan Chemical Structure
Tolvaptan, CAS 150683-30-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 32.00
2 mg In stock $ 45.00
5 mg In stock $ 74.00
10 mg In stock $ 117.00
25 mg In stock $ 217.00
50 mg In stock $ 383.00
100 mg In stock $ 509.00
500 mg In stock $ 1,150.00
1 mL * 10 mM (in DMSO) In stock $ 129.00
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Purity: 99.75%
Purity: 97%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tolvaptan is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.
Targets&IC50 vasopressin receptor 2:3 nM
Kinase Assay Cell-free autophosphorylation assay using time-resolved fluorometry: Neratinib is prepared as 10 mg/mL stocks in DMSO and diluted in 25 mM HEPES (pH 7.5; 0.002 ng/mL-20 μg/mL). Purified recombinant COOH-terminal fragments of HER2 (amino acids 676-1255) or epidermal growth factor receptor (EGFR) (amino acids 645-1186) [diluted in 100 mM HEPES (pH 7.5) and 50% glycerol] is incubated with increasing concentrations of Neratinib in 4 mM HEPES (pH 7.5), 0.4 mM MnCl2, 20 μM sodium vanadate, and 0.2 mM DTT for 15 minutes at room temperature in 96-well ELISA plates. The kinase reaction is initiated by the addition of 40 μM ATP and 20 mM MgCl2 and allowed to proceed for 1 hour at room temperature. Plates are washed, and phosphorylation is detected using Europium-labeled anti-phospho-tyrosine antibodies (15 ng/well). After washing and enhancement steps, signal is detected using a Victor2 fluorescence reader (excitation wavelength 340 nm, emission wavelength 615 nm). The concentration of Neratinib that inhibits receptor phosphorylation by 50% (IC50) is calculated from inhibition curves.
Synonyms OPC-41061
Molecular Weight 448.941
Formula C26H25ClN2O3
CAS No. 150683-30-0


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: 4.5 mg/mL (10 mM)

DMSO: 44.9 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Miyazaki T, et al. Cardiovasc Drug Rev, 2007, 25(1), 1-13. 2. Reif GA, et al. Am J Physiol Renal Physiol, 2011, 301(5), F12005-12013. 3. Veeraveedu PT, et al. Biochem Pharmacol, 2008, 75(6), 1322-1330.

Related compound libraries

This product is contained In the following compound libraries:
Endocrinology-Hormone Compound Library Orally Active Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Drug Library Drug-induced Liver Injury (DILI) Compound Library ReFRAME Related Library Anti-Cancer Clinical Compound Library NO PAINS Compound Library Inhibitor Library Autophagy Compound Library

Related Products

Related compounds with same targets
OPC-51803 Argipressin Atosiban d[Cha4]-AVP acetate(500170-27-4 free base) Conopressin S acetate(111317-90-9 free base) Terlipressin Acetate Felypressin Balovaptan

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