Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Tolvaptan is an orally bioavailable, selective, arginine Vasopressin Receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 32.00 | |
2 mg | In stock | $ 45.00 | |
5 mg | In stock | $ 74.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 217.00 | |
50 mg | In stock | $ 383.00 | |
100 mg | In stock | $ 509.00 | |
500 mg | In stock | $ 1,150.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 129.00 |
Description | Tolvaptan is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia. |
Targets&IC50 | vasopressin receptor 2:3 nM |
Kinase Assay | Cell-free autophosphorylation assay using time-resolved fluorometry: Neratinib is prepared as 10 mg/mL stocks in DMSO and diluted in 25 mM HEPES (pH 7.5; 0.002 ng/mL-20 μg/mL). Purified recombinant COOH-terminal fragments of HER2 (amino acids 676-1255) or epidermal growth factor receptor (EGFR) (amino acids 645-1186) [diluted in 100 mM HEPES (pH 7.5) and 50% glycerol] is incubated with increasing concentrations of Neratinib in 4 mM HEPES (pH 7.5), 0.4 mM MnCl2, 20 μM sodium vanadate, and 0.2 mM DTT for 15 minutes at room temperature in 96-well ELISA plates. The kinase reaction is initiated by the addition of 40 μM ATP and 20 mM MgCl2 and allowed to proceed for 1 hour at room temperature. Plates are washed, and phosphorylation is detected using Europium-labeled anti-phospho-tyrosine antibodies (15 ng/well). After washing and enhancement steps, signal is detected using a Victor2 fluorescence reader (excitation wavelength 340 nm, emission wavelength 615 nm). The concentration of Neratinib that inhibits receptor phosphorylation by 50% (IC50) is calculated from inhibition curves. |
Synonyms | OPC-41061 |
Molecular Weight | 448.941 |
Formula | C26H25ClN2O3 |
CAS No. | 150683-30-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Ethanol: 4.5 mg/mL (10 mM)
DMSO: 44.9 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tolvaptan 150683-30-0 Autophagy GPCR/G Protein Vasopressin Receptor antidiuretic hormone Inhibitor cell cycle inhibit OPC-41061 hyponatremia SIADH OPC 41061 apoposis OPC41061 inhibitor