Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tianeptine (Tianeptine sodium) is a selective 5-HT uptake facilitator in vitro and in vivo.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 81.00 | |
50 mg | In stock | $ 122.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Tianeptine (Tianeptine sodium) is a selective 5-HT uptake facilitator in vitro and in vivo. |
In vivo | tianeptine pretreatment upon corticosterone release and body weight loss following L-5-hydroxytryptophan (5-HTP) administration in conscious rats.?Administration of 5-HTP (20 mg/kg i.v.) increased plasma corticosterone levels to a similar extent in rats pretreated either with saline or tianeptine (10 mg/kg i.p., 60 min beforehand).?Besides, prior administration of benserazide (50 mg/kg i.p., 30 min beforehand), an inhibitor of peripheral aromatic L-amino acid decarboxylase, prevented 5-HTP-induced corticosterone release in both saline- and tianeptine-pretreated rats.?However, combined administration of benserazide and 5-HTP decreased overnight body weight in saline-, but not in tianeptine-pretreated rats.?These results suggest that tianeptine preferentially activates 5-HT reuptake in central serotonergic neurones. |
Synonyms | S-1574, JNJ-39823277, Tianeptine sodium, TPI-1062 |
Molecular Weight | 436.95 |
Formula | C21H25ClN2O4S |
CAS No. | 72797-41-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (22.89 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Tianeptine 72797-41-2 GPCR/G Protein Neuroscience 5-HT Receptor S1574 JNJ 39823277 S-1574 Serotonin Receptor TPI1062 JNJ-39823277 JNJ39823277 Inhibitor inhibit Tianeptine sodium S 1574 TPI 1062 5-hydroxytryptamine Receptor TPI-1062 inhibitor