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Telocinobufagin

Name: Telocinobufagin
Brand: TargetMol
SKU: T4A2462
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4A2462Cas No. 472-26-4

Alias Telocinobufogenin, Telobufotoxin

1. Telocinobufagin (Telobufotoxin) is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice challenged with live S. typhimurium. 3. Telocinobufagin has immunomodulatory activity, can enhance a Th1 immune response to control intracellular infections, could be developed as a novel immunotherapeutic agent to treat cancer and other immune-mediated diseases.

Telocinobufagin

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Purity: 99.74%

Catalog No. T4A2462Alias Telocinobufogenin, TelobufotoxinCas No. 472-26-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$54	In Stock	In Stock
5 mg	$132	In Stock	In Stock
10 mg	$211	In Stock	In Stock
25 mg	$375	In Stock	In Stock
50 mg	$550	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$147	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Telocinobufagin AI Summary

Telocinobufagin exhibits broad cytotoxic activity against various human cancer cell lines. It shows potent inhibitory activity against the primary liver carcinoma (PLC) cell line PLC/PRF/5 with an IC50 value of 0.000345 µg/mL and against colchicine-resistant PLC/PRF/5 cells with an IC50 value of 0.0026 µg/mL. Additionally, it exhibits cytotoxicity against human KB cells (IC50 = 1.3 µg/mL) and human HL60 cells (IC50 < 0.01 µg/mL), while displaying no significant activity against mouse MH60 cells (IC50 > 25.0 µg/mL). For human A549 cells, the IC50 is 3000.0 nM, and for human HepG2 cells, it is 2400.0 nM after 24 hours. Furthermore, it shows strong cytotoxicity against human SK-MEL cells with an IC50 of 50.0 nM. In multiple human cell lines, the IC50 ranges from 106.6 nM to 618.5 nM. The compound can also induce apoptosis in PC-9 and NCI-H1299 cells and exhibits binding affinity to STAT3 with a dissociation constant (KD) of 50300.0 nM. Lastly, it maintains 100% cell viability for KM mouse splenic lymphocytes at 5 µM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Telocinobufogenin, Telobufotoxin

Chemical Properties

Molecular Weight	402.52
Formula	C₂₄H₃₄O₅
Cas No.	472-26-4
Smiles	[H][C@@]12CC[C@]3(O)C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@]21O)c1ccc(=O)oc1
Relative Density.	1.311g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (149.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4843 mL	12.4217 mL	24.8435 mL	124.2174 mL
5 mM	0.4969 mL	2.4843 mL	4.9687 mL	24.8435 mL
10 mM	0.2484 mL	1.2422 mL	2.4843 mL	12.4217 mL
20 mM	0.1242 mL	0.6211 mL	1.2422 mL	6.2109 mL
50 mM	0.0497 mL	0.2484 mL	0.4969 mL	2.4843 mL
100 mM	0.0248 mL	0.1242 mL	0.2484 mL	1.2422 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc