Shopping Cart

Your shopping cart is currently empty

Telbivudine

Name: Telbivudine
Brand: TargetMol
SKU: T1513
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1513Cas No. 3424-98-4

Alias NV 02B, L-Thymidine, Epavudine

Telbivudine (NV 02B) is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse Transcriptase Inhibitor. The chemical classification of telbivudine is Nucleoside Analog.

Telbivudine

Copy Product Info

🥰Excellent

Purity: 99.94%

Catalog No. T1513Alias NV 02B, L-Thymidine, EpavudineCas No. 3424-98-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$158	In Stock	In Stock
100 mg	$222	In Stock	In Stock
200 mg	$328	In Stock	In Stock
500 mg	$552	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Telbivudine (NV 02B) is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse Transcriptase Inhibitor. The chemical classification of telbivudine is Nucleoside Analog.
In vivo	Telbivudine significantly increases the levels of tumor necrosis factor-alpha and interleukin-2 in macrophages (induced by MHV-3) as well as serum levels of interferon-gamma. It is phosphorylated by cellular thymidine kinase into an active triphosphate form, with an intracellular half-life of 14 hours. While enhancing the proliferation and secretion capabilities of T-cells, Telbivudine does not affect the cytotoxicity against infected hepatocytes. Furthermore, it inhibits the expression of programmed death ligand 1 in T-cells. Despite mutations such as N236T and A181V/A194T, Telbivudine remains active at increased magnitudes of 0.5 and 1.0 times, respectively. The differences in resistance between lamivudine and Telbivudine are due to Telbivudine's inactivity against the lamivudine-resistant HBV strain L180M/M204V/I mutation, though it remains active against the M204V single mutation.
Synonyms	NV 02B, L-Thymidine, Epavudine

Chemical Properties

Molecular Weight	242.23
Formula	C₁₀H₁₄N₂O₅
Cas No.	3424-98-4
Smiles	Cc1cn([C@@H]2C[C@@H](O)[C@H](CO)O2)c(=O)[nH]c1=O
Relative Density.	1.452 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 44 mg/mL (181.65 mM), Sonication is recommended.

DMSO: 50 mg/mL (206.42 mM), Sonication is recommended.

Ethanol: 2 mg/mL (8.26 mM), Heating is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (10.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1283 mL	20.6415 mL	41.2831 mL	206.4154 mL
5 mM	0.8257 mL	4.1283 mL	8.2566 mL	41.2831 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
10 mM	0.4128 mL	2.0642 mL	4.1283 mL	20.6415 mL
20 mM	0.2064 mL	1.0321 mL	2.0642 mL	10.3208 mL
50 mM	0.0826 mL	0.4128 mL	0.8257 mL	4.1283 mL
100 mM	0.0413 mL	0.2064 mL	0.4128 mL	2.0642 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc