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TH5487

Catalog No. T8119 CAS 2304947-71-3

TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)

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TH5487, CAS 2304947-71-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 40.00
2 mg	In stock	$ 57.00
5 mg	In stock	$ 95.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 319.00
50 mg	In stock	$ 578.00
100 mg	In stock	$ 833.00
500 mg	In stock	$ 1,690.00
1 mL * 10 mM (in DMSO)	In stock	$ 113.00

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Purity: 98.83%

Purity: 96.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)
Targets&IC50	OGG1:342 nM
In vitro	TH5487 Inhibited proinflammatory gene expression dose-dependently.
In vivo	TH5487 (prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours) decreases TNFα or LPS induced the robust recruitment of neutrophils to the airways, and reduces the pulmonary neutrophil count in a time-dependent manner. TH5487 InterruptedTNFα-induced ongoing inflammatory processes.
Cell Research	Cell Line:Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs). Concentration:5 μM. Incubation Time:1 hour
Animal Research	Animal Model:Eightweek-old female and male BALB/c mice. Dosage:8 mg/kg, 15 mg/kg, 30 mg/kg. Administration:Prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours

Molecular Weight	541.18
Formula	C19H18BrIN4O2
CAS No.	2304947-71-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (46.20 mM), Sonication is recommended.

References and Literature

1. Visnes T, et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library DNA Damage & Repair Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TH5487 2304947-71-3 Others Inhibitor inhibit TH-5487 TH 5487 inhibitor

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