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TAK-615

TAK-615
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TAK-615

Catalog No. T9699Cas No. 1664335-55-0
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$69In Stock
5 mg$172In Stock
10 mg$273In Stock
25 mg$451In Stock
50 mg$636In Stock
100 mg$858In Stock
500 mg$1,710In Stock
1 mL x 10 mM (in DMSO)$190In Stock
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Product Introduction

Bioactivity
Description
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
In vitro
TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity of 1.7 ± 0.5 nM and Kd low affinity of 14.5 ± 12.1 nM. TAK-615 is only able to partically inhibit the LPA response (~40% at 10 μM with an IC50 of 23 ± 13 nM in β-arrestin assay; 60% at 10 μM, IC50 of 91 ± 30 nM in calcuim mobilisation assay). [1]
Chemical Properties
Molecular Weight419.44
FormulaC25H22FNO4
Cas No.1664335-55-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 120 mg/mL (286.10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3841 mL11.9207 mL23.8413 mL119.2066 mL
5 mM0.4768 mL2.3841 mL4.7683 mL23.8413 mL
10 mM0.2384 mL1.1921 mL2.3841 mL11.9207 mL
20 mM0.1192 mL0.5960 mL1.1921 mL5.9603 mL
50 mM0.0477 mL0.2384 mL0.4768 mL2.3841 mL
100 mM0.0238 mL0.1192 mL0.2384 mL1.1921 mL

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