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TAK-615

Catalog No. T9699 CAS 1664335-55-0

TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.

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TAK-615, CAS 1664335-55-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
In vitro	TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity of 1.7 ± 0.5 nM and Kd low affinity of 14.5 ± 12.1 nM. TAK-615 is only able to partically inhibit the LPA response (~40% at 10 μM with an IC50 of 23 ± 13 nM in β-arrestin assay; 60% at 10 μM, IC50 of 91 ± 30 nM in calcuim mobilisation assay). [1]

Molecular Weight	419.44
Formula	C25H22FNO4
CAS No.	1664335-55-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 120 mg/mL (286.10 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jonathan Ellery, et al. Identification of compounds acting as negative allosteric modulators of the LPA 1 receptor. Eur J Pharmacol. 2018 Aug 15;833:8-15.

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Keywords

TAK-615 1664335-55-0 GPCR/G Protein LPA Receptor LPA1 fibrosis LPL Receptor Lysophospholipid Receptor TAK615 modulator NAM inhibit pulmonary Inhibitor allosteric TAK 615 negative inhibitor

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