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TAK-615

Name: TAK-615
Brand: TargetMol
SKU: T9699
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9699Cas No. 1664335-55-0

TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.

TAK-615

🥰Excellent

Purity: 99.73%

Catalog No. T9699Cas No. 1664335-55-0

TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.

Pack Size	Price	Availability
1 mg	$69	In Stock
5 mg	$172	In Stock
10 mg	$273	In Stock
25 mg	$451	In Stock
50 mg	$636	In Stock
100 mg	$858	In Stock
500 mg	$1,710	In Stock
1 mL x 10 mM (in DMSO)	$190	In Stock

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Batch Information

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Purity:99.73%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
Targets&IC50	LPA1 Receptor:1.7-14.5 nM (Kd)
In vitro	TAK-615 specifically binds to membranes expressing the human LPA1 receptor with high affinity (Kd = 1.7 ± 0.5 nM) and low affinity (Kd = 14.5 ± 12.1 nM). TAK-615 partially inhibits the LPA response (~40% at 10 μM, IC50 = 23 ± 13 nM in β-arrestin assay; 60% at 10 μM, IC50 = 91 ± 30 nM in calcium mobilization assay). [1]

Chemical Properties

Molecular Weight	419.44
Formula	C₂₅H₂₂FNO₄
Cas No.	1664335-55-0
Smiles	OC(=O)c1ccc(CN(CC2CC2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1
Relative Density.	1.302 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (286.10 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3841 mL	11.9207 mL	23.8413 mL	119.2066 mL
5 mM	0.4768 mL	2.3841 mL	4.7683 mL	23.8413 mL
10 mM	0.2384 mL	1.1921 mL	2.3841 mL	11.9207 mL
20 mM	0.1192 mL	0.5960 mL	1.1921 mL	5.9603 mL
50 mM	0.0477 mL	0.2384 mL	0.4768 mL	2.3841 mL
100 mM	0.0238 mL	0.1192 mL	0.2384 mL	1.1921 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc