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Sugammadex sodium

Catalog No. T5326 CAS 343306-79-6

Synonyms: Org25969, Sugammadex (sodium)

Sugammadex sodium (Org25969) , a synthetic derivative of γ-cyclodextrin, is a steroid-based neuromuscular blocker reversing agent.

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Sugammadex sodium, CAS 343306-79-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 54.00
25 mg	In stock	$ 86.00
50 mg	In stock	$ 117.00
100 mg	In stock	$ 163.00
200 mg	In stock	$ 263.00
500 mg	In stock	$ 493.00

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Purity: 99.44%

Purity: 99.43%

Biological Description

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Storage & Solubility Information

Description	Sugammadex sodium (Org25969) , a synthetic derivative of γ-cyclodextrin, is a steroid-based neuromuscular blocker reversing agent.
In vivo	Injection of 100 microg/kg rocuronium resulted in a mean neuromuscular blockade of 93.0%, and profound blockade was achieved by injection of 500 microg/kg. After injection of the high rocuronium dose, the 90% recovery of the train-of-four ratio took 28 min after saline, 26 min after 1 mg/kg sugammadex, and 8 min after 2.5 mg/kg sugammadex. Signs of residual blockade or recurarization were not observed [1]. Treatment with 16 mg/kg and 100 mg/kg sugammadex had a neuroprotective effect in a transient global cerebral I/R rat model. However, 100 mg/kg sugammadex was more neuroprotective in rats [2].
Animal Research	The animals were anesthetized with 80 mg/kg ketamine hydrochloride and 12 mg/kg xylazine administered intraperitoneally. After the rats were anesthetized, the bilateral common carotid arteries were exposed and carefully separated from the carotid sheath and the cervical sympathetic and vagal nerves through a ventral cervical incision. The bilateral common carotid arteries were occluded with nontraumatic aneurysm clips in ischemic rats but were not clamped in sham-operated rats. Complete interruption of the blood flow was confirmed by observing the central artery in the retina with an ophthalmoscope. The body temperature of the rats was maintained at 37.0 ± 0.5°C during this procedure. In this model, 10 minutes of ischemia and 24 hours of reperfusion were induced. After the ischemic period, the rats were treated with sugammadex 16 mg/kg (S 16 group) and sugammadex 100 mg/kg (S 100 group) (intravenous and total volume 1 mL) in the 5th minute of reperfusion. Sugammadex was diluted with normal saline (0.9% NaCl). The same surgical procedure was performed in the I/R group, but the rats were not treated with sugammadex. The neck incision was closed with sutures (3.0 silk), and the animals were allowed to awaken. After 24 hours, the neurological condition of the rats was assessed with a scoring system [2].

Synonyms	Org25969, Sugammadex (sodium)
Molecular Weight	2178.01
Formula	C72H104Na8O48S8
CAS No.	343306-79-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 34 mg/mL (15.61 mM)

References and Literature

1. de Boer HD, et al. Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. Anesthesiology. 2006 Apr;104(4):718-23. 2. Ozbilgin S, et al. Effectiveness of sugammadex for cerebral ischemia/reperfusion injury. Kaohsiung J Med Sci. 2016 Jun;32(6):292-301.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Macrocyclic Compound Library

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Keywords

Sugammadex sodium 343306-79-6 Others inhibit Inhibitor anesthesia Sugammadex Org 25969 reversal agent neuromuscular block ischemic Org25969 Org-25969 Sugammadex (sodium) Neuroprotective inhibitor

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