Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Eri<a href="/target/Smo" style="display: inline; color: #c13a36">Smo</a>degib diphosphate is an effective and selective <a href="/target/Smo" style="display: inline; color: #c13a36">Smo</a> antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human <a href="/target/Smo" style="display: inline; color: #c13a36">Smo</a> in a binding assay, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 48.00 | |
10 mg | In stock | $ 56.00 | |
25 mg | In stock | $ 101.00 | |
50 mg | In stock | $ 118.00 | |
100 mg | In stock | $ 204.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | Erismodegib diphosphate is an effective and selective Smo antagonist (IC50: 1.3 nM and 2.5 nM for mouse and human Smo in a binding assay, respectively). |
Targets&IC50 | hSmo:2.5 nM (IC50), mSmo:1.3 nM (IC50) |
In vitro | Erismodegib diphosphate, a small molecule, clinically investigated SMO inhibitor. Erismodegib diphosphate is used alone and in combination with Nilotinib, inhibits the Hh pathway in CD34+ chronic phase (CP)-chronic myeloid leukaemia (CML) cells, reducing the number and self-renewal capacity of CML leukaemia stem cell (LSC). In a similar fashion to cyclopamine, Erismodegib interacts directly with SMO, to reduce the expression of downstream Hh signaling targets. The IC50 values for Erismodegib diphosphate for the major human CYP450 drug-metabolizing enzymes are greater than 10 μM. Primary CD34+ CP-CML cells are cultured in serum-free media (SFM)±Erismodegib for 6, 24, and 72 hours (h). At 72 h, while there is variability between the biological samples, GLI1 is obviously downregulated following exposure to Erismodegib (10 nM; 0.78-fold and 100 nM; 0.73-fold, respectively (p<0.01)[2]. |
In vivo | Erismodegib diphosphate is a weak base with a measured pKa of 4.2 and exhibits relatively poor aqueous solubility. Erismodegib diphosphate demonstrates dose-related antitumor activity after 10 days of oral administration of a suspension of the diphosphate salt, in the subcutaneous Ptch+/-p53-/- medulloblastoma allograft mouse model. Bone marrow cells and spleen cells from a subset of treated mice are transplanted into secondary recipient mice. Erismodegib diphosphate (5 mg/kg/day; once daily) obviously inhibits tumor growth, corresponding to a T/C value of 33% (p<0.05 as compared to vehicle controls). Erismodegib affords 51 and 83% regression respectively when dosed at 10 and 20 mg/kg/day qd [1]. Transplantation of either bone marrow (BM) or spleen cells from mice treated with Erismodegib diphosphate+ Nilotinib results in reduced white cell count (WCC) and reduces leukaemia development in secondary recipients compared to Erismodegib or Nilotinib alone[2]. |
Synonyms | Erismodegib diphosphate, NVP-LDE 225 diphosphate, LDE225 diphosphate |
Molecular Weight | 681.49 |
Formula | C26H32F3N3O11P2 |
CAS No. | 1218778-77-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 99 mg/mL(145.27 mM)
H2O: Insoluble
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Sonidegib diphosphate 1218778-77-8 Stem Cells Smo NVP-LDE225 diphosphate Inhibitor Smoothened inhibit Erismodegib diphosphate NVP-LDE 225 diphosphate LDE225 diphosphate inhibitor