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Scopine

Name: Scopine
Brand: TargetMol
SKU: T6662
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6662Cas No. 498-45-3

Alias 6,7-Epoxytropine

Scopine (6,7-Epoxytropine), the metabolite of anisodine, is an α1-adrenergic receptor agonist used in the therapy of acute circulatory shock.

Scopine

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Purity: 99.82%

Catalog No. T6662Alias 6,7-EpoxytropineCas No. 498-45-3

Scopine (6,7-Epoxytropine), the metabolite of anisodine, is an α1-adrenergic receptor agonist used in the therapy of acute circulatory shock.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$116	In Stock	In Stock
50 mg	$178	In Stock	In Stock
100 mg	$312	In Stock	In Stock
200 mg	$466	In Stock	In Stock
500 mg	$747	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Scopine AI Summary

Scopine exhibits antiviral activity and enzymatic inhibition properties. Specifically, it shows inhibition of SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cell lines at 10 µM after 48 hours, with inhibition rates of -0.97% and 0.16%, respectively. Additionally, the compound inhibits the SARS-CoV-2 3CL-Pro protease by approximately 10.56% at a 20 µM concentration, as determined using a FRET assay with a peptide substrate. In enzymatic assays targeting human HDAC6, Scopine demonstrates significant inhibition at 91.42% with a commercial peptide substrate, moderate inhibition at 67.88% with a custom peptide substrate, and minimal inhibition at 4.89% with another distinct custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Scopine (6,7-Epoxytropine), the metabolite of anisodine, is an α1-adrenergic receptor agonist used in the therapy of acute circulatory shock.
Synonyms	6,7-Epoxytropine

Chemical Properties

Molecular Weight	155.19
Formula	C₈H₁₃NO₂
Cas No.	498-45-3
Smiles	CN1C2CC(O)CC1C1OC21
Relative Density.	1.284 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (322.19 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4437 mL	32.2186 mL	64.4371 mL	322.1857 mL
5 mM	1.2887 mL	6.4437 mL	12.8874 mL	64.4371 mL
10 mM	0.6444 mL	3.2219 mL	6.4437 mL	32.2186 mL
20 mM	0.3222 mL	1.6109 mL	3.2219 mL	16.1093 mL
50 mM	0.1289 mL	0.6444 mL	1.2887 mL	6.4437 mL
100 mM	0.0644 mL	0.3222 mL	0.6444 mL	3.2219 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc