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Salvianolic acid A

Salvianolic acid A
Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.
Catalog No. T6S0444Cas No. 96574-01-5
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Salvianolic acid A

Catalog No. T6S0444Cas No. 96574-01-5
Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$45In Stock
10 mg$72In Stock
25 mg$146In Stock
50 mg$217In Stock
100 mg$326In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Product Introduction

Bioactivity
Description
Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.
In vitro
METHODS: Five tumor cell lines, SKOV3, HeLa, NCI-H1975, DU145 and A549, were treated with Salvianolic acid A (1.56-100 µM) for 72 h. Cell viability was measured by CellTiter-Glo kit.
RESULTS: The growth of SKOV3, HeLa, NCI-H1975, DU145 and A549 cells was inhibited with increasing concentrations of Salvianolic acid A, with IC50s of 30.84 µM, 15.85 µM, 10.19 µM, 9.512 µM and 6.461 µM, respectively. [1]
METHODS: Rat cardiomyocytes H9C2 were treated with Salvianolic acid A (50 µM) and Doxorubicin (4 µM) for 12 h. Apoptosis was detected by TUNEL assay.
RESULTS: The number of apoptotic cells increased significantly after Dox stimulation. H9C2 cells co-treated with Dox and Salvianolic acid A exhibited significantly lower apoptosis rates compared to cells exposed to Dox. Salvianolic acid A inhibited Dox-induced apoptosis in H9C2 cells. [2]
In vivo
METHODS: In order to investigate the effects on amnesia in mice, Salvianolic acid A (10-40 mg/kg) was administered orally once daily for five days to a C57BL/6 mouse model of amnesia induced by diazepam.
RESULTS: Salvianolic acid A exerts an antiamnesic effect on diazepam-induced paracrine amnesia in mice by enhancing the antioxidant capacity of the hippocampus. [3]
AliasDan Phenolic Acid A
Chemical Properties
Molecular Weight494.45
FormulaC26H22O10
Cas No.96574-01-5
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (91.01 mM)
10% DMSO+90% Saline: 13 mg/mL (26.29 mM), Working solution is recommended to be prepared and used immediately.
Ethanol: 10 mg/mL
Solution Preparation Table
10% DMSO+90% Saline/DMSO
1mg5mg10mg50mg
1 mM2.0224 mL10.1122 mL20.2245 mL101.1225 mL
5 mM0.4045 mL2.0224 mL4.0449 mL20.2245 mL
10 mM0.2022 mL1.0112 mL2.0224 mL10.1122 mL
20 mM0.1011 mL0.5056 mL1.0112 mL5.0561 mL
DMSO
1mg5mg10mg50mg
50 mM0.0404 mL0.2022 mL0.4045 mL2.0224 mL

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