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Salvianolic acid A

Name: Salvianolic acid A
Brand: TargetMol
SKU: T6S0444
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S0444Cas No. 96574-01-5

Alias Dan Phenolic Acid A

Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.

Salvianolic acid A

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Purity: 99.98%

Catalog No. T6S0444Alias Dan Phenolic Acid ACas No. 96574-01-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$45	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$146	In Stock	In Stock
50 mg	$217	In Stock	In Stock
100 mg	$326	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Salvianolic acid A AI Summary

Salvianolic acid A exhibits a range of bioactivities across various biological targets. It shows significant antioxidant activity against Cu2+-induced lipid peroxidation in human plasma LDL with an IC50 value of 590.0 nM, and it’s relatively potent compared to probucol with a value of 7.3. It inhibits the LCK and c-SRC SH2 domains with IC50 values of 23,500.0 nM and 36,200.0 nM respectively, and demonstrates partial inhibition of STAT1, STAT3, and STAT5b SH2 domains at 200 µM. The compound has a very low bioavailability of 1.47% in beagle dogs. Moreover, Salvianolic acid A shows potent inhibition of carbonic anhydrase isoforms, specifically CA4, CA7, and CA12 with Ki values of 66.6 nM, 71.4 nM, and 39.8 nM, respectively, and moderate inhibition of CA2 with a Ki of 9,594.4 nM. Its inhibition of CA1 is weak, indicated by a Ki value exceeding 10,000.0 nM. Additionally, it inhibits Cav1.2 calcium currents in rat ventricular myocytes with an IC50 of 38,300.0 nM, indicating potential regulatory effects on calcium channels. In antibacterial assays, Salvianolic acid A inhibits bacterial enzymes VIM2, NDM1, and TEM1 with IC50 values between 26,915.35 nM to 177,827.94 nM, and enhances the efficacy of meropenem against Escherichia coli, thus showing synergistic antibiotic potential. The compound also displays antiproliferative activity against MOLM13, MOLM14, and MV4-11 human cancer cell lines with respective IC50 values of 2,500.0 nM, 6,200.0 nM, and >10,000.0 nM, suggesting a possible role as an anticancer agent. Furthermore, Salvianolic acid A exhibits moderate binding affinity to the human P2Y1 receptor, with a Ki value of 20,300.0 nM. All these activities highlight the compound's broad pharmacological profile and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.
In vitro	METHODS: Five tumor cell lines, SKOV3, HeLa, NCI-H1975, DU145 and A549, were treated with Salvianolic acid A (1.56-100 µM) for 72 h. Cell viability was measured by CellTiter-Glo kit. RESULTS: The growth of SKOV3, HeLa, NCI-H1975, DU145 and A549 cells was inhibited with increasing concentrations of Salvianolic acid A, with IC50s of 30.84 µM, 15.85 µM, 10.19 µM, 9.512 µM and 6.461 µM, respectively. [1] METHODS: Rat cardiomyocytes H9C2 were treated with Salvianolic acid A (50 µM) and Doxorubicin (4 µM) for 12 h. Apoptosis was detected by TUNEL assay. RESULTS: The number of apoptotic cells increased significantly after Dox stimulation. H9C2 cells co-treated with Dox and Salvianolic acid A exhibited significantly lower apoptosis rates compared to cells exposed to Dox. Salvianolic acid A inhibited Dox-induced apoptosis in H9C2 cells. [2]
In vivo	METHODS: In order to investigate the effects on amnesia in mice, Salvianolic acid A (10-40 mg/kg) was administered orally once daily for five days to a C57BL/6 mouse model of amnesia induced by diazepam. RESULTS: Salvianolic acid A exerts an antiamnesic effect on diazepam-induced paracrine amnesia in mice by enhancing the antioxidant capacity of the hippocampus. [3]
Synonyms	Dan Phenolic Acid A

Chemical Properties

Molecular Weight	494.45
Formula	C₂₆H₂₂O₁₀
Cas No.	96574-01-5
Smiles	OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1\C=C\c1ccc(O)c(O)c1
Relative Density.	1.580 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 85 mg/mL (171.91 mM), Sonication is recommended.

Ethanol: 10 mg/mL (20.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 13 mg/mL (26.29 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0224 mL	10.1122 mL	20.2245 mL	101.1225 mL
5 mM	0.4045 mL	2.0224 mL	4.0449 mL	20.2245 mL
10 mM	0.2022 mL	1.0112 mL	2.0224 mL	10.1122 mL
20 mM	0.1011 mL	0.5056 mL	1.0112 mL	5.0561 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0404 mL	0.2022 mL	0.4045 mL	2.0224 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0112 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc