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Saikogenin D

Catalog No. TN2169 CAS 5573-16-0

Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores. Saikogenin D has immunomodulatory effect, it can attenuate IL-6 production in LPS-stimulated alveolar macrophages of B6 more than in that of BALB.

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Saikogenin D, CAS 5573-16-0

Pack Size	Availability	Price/USD	Quantity
5 mg	5 days	$ 241.00
1 mL * 10 mM (in DMSO)	5 days	$ 460.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores. Saikogenin D has immunomodulatory effect, it can attenuate IL-6 production in LPS-stimulated alveolar macrophages of B6 more than in that of BALB.
In vitro	Saikogenin D (1-20 microM) inhibited PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with the IC50 of about 3 microM. Saikogenin D did not affect the conversion of arachidonic acid into PGE2 in microsomal preparations. On the other hand, Saikogenin D elevated [Ca2+]i in a concentration-dependent manner (10-100 microM) with the EC50 value of about 35 microM in the presence or absence of extracellular Ca2+.
Source	Natural Products > Apiaceae > Bupleurum

Molecular Weight	472.7
Formula	C30H48O4
CAS No.	5573-16-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.Planta Medica, 2003, 69(8):765.

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Keywords

Saikogenin D 5573-16-0 GPCR/G Protein Immunology/Inflammation Membrane transporter/Ion channel Metabolism IL Receptor Calcium Channel Prostaglandin Receptor inhibitor inhibit

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