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Rupintrivir

Catalog No. T16809 CAS 223537-30-2

Synonyms: AG-7088, AG7088, Rupintrivirvr

Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Rupintrivir, CAS 223537-30-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 118.00
5 mg	In stock	$ 287.00
10 mg	In stock	$ 455.00
25 mg	In stock	$ 747.00
50 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 369.00

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Purity: 99.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.
In vitro	In H1-HeLa and MRC-5 cell protection assays, Rupintrivir (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50) of 0.023 microM (range, 0.003 to 0.081 microM) and a mean EC90 of 0.082 microM (range, 0.018 to 0.261 microM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11[1].
In vivo	PCLS from HDM-sensitized mice showed an attenuated antiviral response, but exaggerated IL-4, IL-6, and IL-10 secretion upon infection. Rupintrivir(AG7088) inhibited exaggerated pro-inflammatory cytokine IL-6 and TH-2 cytokine IL-4 in HDM-sensitized mice[2].

Synonyms	AG-7088, AG7088, Rupintrivirvr
Molecular Weight	598.66
Formula	C31H39FN4O7
CAS No.	223537-30-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (50.11 mM), Sonication is recommended.

References and Literature

1. Patick AK, et al. In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50. 2. Danov O, et al. Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. Respir Res. 2019 Oct 22;20(1):228. 3. Dragovich PS, et al. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem. 1999 Apr 8;42(7):1203-12.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rupintrivir 223537-30-2 Immunology/Inflammation Microbiology/Virology Virus Protease Antiviral AG-7088 AG7088 Rupintrivirvr AG 7088 inhibitor inhibit

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