Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 30.00 | |
10 mg | In stock | $ 48.00 | |
25 mg | In stock | $ 79.00 | |
50 mg | In stock | $ 116.00 | |
100 mg | In stock | $ 178.00 | |
500 mg | In stock | $ 453.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 31.00 |
Description | SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression. |
Targets&IC50 | IKK2:11.2±4.7 μM |
In vitro | In nude mice implanted with A375 or G361 tumors, daily treatment was administered with SC-514 (25 mg/kg). |
In vivo | In rheumatoid arthritis synovial fibroblasts (RASFs), SC-514 (100 μM) inhibits the phosphorylation and degradation of IκBα, while also preventing the translocation of p65 into the nucleus. In the presence of IL-1β-induced inflammation, SC-514 effectively suppresses the expression of NF-κB-dependent genes: IL-6 (IC50=20 μM), IL-8 (IC50=20 μM), and COX-2 (IC50=8 μM). |
Synonyms | GK 01140 |
Molecular Weight | 224.3 |
Formula | C9H8N2OS2 |
CAS No. | 354812-17-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.4 mg/mL (100 mM)
Ethanol: 2.2 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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SC-514 354812-17-2 Cell Cycle/Checkpoint Chromatin/Epigenetic MAPK NF-Κb Proteases/Proteasome CDK IκB/IKK p38 MAPK Serine Protease Aurora Kinase IKK I kappa B kinase GK01140 SC514 GK-01140 GK 01140 SC 514 IκB kinase Inhibitor inhibit inhibitor