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S-trityl-L-Cysteine

Catalog No. T36816   CAS 2799-07-7
Synonyms: STLC

S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5

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S-trityl-L-Cysteine Chemical Structure
S-trityl-L-Cysteine, CAS 2799-07-7
Pack Size Availability Price/USD Quantity
25 mg In stock $ 30.00
50 mg In stock $ 39.00
100 mg In stock $ 55.00
200 mg In stock $ 80.00
500 mg In stock $ 133.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Purity: 97.02%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5
Targets&IC50 Eg5:500 nm
In vitro In vitro, S-trityl-L-Cysteine targets the catalytic domain of Eg5 and inhibits Eg5 basal and microtubule-activated ATPase activity as well as mant-ADP release. S-trityl-L-Cysteine is a tight binding inhibitor (estimation of K(i,app) <150 nm at 300 mm NaCl and 600 nm at 25 mm KCl). S-trityl-L-Cysteine binds more tightly than monastrol because it has both an approximately 8-fold faster association rate and approximately 4-fold slower release rate (6.1/microM/s and 3.6/s for S-trityl-L-Cysteine versus 0.78 /microM/s and 15/s for monastrol). S-trityl-L-Cysteine inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nm[2].
Synonyms STLC
Molecular Weight 363.47
Formula C22H21NO2S
CAS No. 2799-07-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

Methanol: 1 mg/mL

TargetMolReferences and Literature

1. Wu W, et al. S-trityl-L-cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma. Oncol Lett. 2018 Jul;16(1):1023-1030. 2. Skoufias DA, et al. S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression. J Biol Chem. 2006 Jun 30;281(26):17559-69.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Peptide Compound Library Microtubule-Targeted Compound Library Anti-Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library Bioactive Compounds Library Max Inhibitor Library

Related Products

Related compounds with same targets
Eg5 Inhibitor V, trans-24 PF-2771 Empesertib Eg5-IN-1 SR31527 Mps1-IN-3 (S)-Monastrol Dimethylenastron

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Keywords

S-trityl-L-Cysteine 2799-07-7 Cytoskeletal Signaling Kinesin S-Tritylcysteine StritylLCysteine Apoptosis 328542 inhibit cell cycle arrest Inhibitor NSC 83265 antitumor activities NSC-83265 ATPase activity kinesin Eg5 NSC83265 STLC S trityl L Cysteine inhibitor

 

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