Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 30.00 | |
50 mg | In stock | $ 39.00 | |
100 mg | In stock | $ 55.00 | |
200 mg | In stock | $ 80.00 | |
500 mg | In stock | $ 133.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5 |
Targets&IC50 | Eg5:500 nm |
In vitro | In vitro, S-trityl-L-Cysteine targets the catalytic domain of Eg5 and inhibits Eg5 basal and microtubule-activated ATPase activity as well as mant-ADP release. S-trityl-L-Cysteine is a tight binding inhibitor (estimation of K(i,app) <150 nm at 300 mm NaCl and 600 nm at 25 mm KCl). S-trityl-L-Cysteine binds more tightly than monastrol because it has both an approximately 8-fold faster association rate and approximately 4-fold slower release rate (6.1/microM/s and 3.6/s for S-trityl-L-Cysteine versus 0.78 /microM/s and 15/s for monastrol). S-trityl-L-Cysteine inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nm[2]. |
Synonyms | STLC |
Molecular Weight | 363.47 |
Formula | C22H21NO2S |
CAS No. | 2799-07-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
Methanol: 1 mg/mL
You can also refer to dose conversion for different animals. More
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S-trityl-L-Cysteine 2799-07-7 Cytoskeletal Signaling Kinesin S-Tritylcysteine StritylLCysteine Apoptosis 328542 inhibit cell cycle arrest Inhibitor NSC 83265 antitumor activities NSC-83265 ATPase activity kinesin Eg5 NSC83265 STLC S trityl L Cysteine inhibitor