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Neuroscience AChR Ribavirin

Ribavirin

Catalog No. T0684   CAS 36791-04-5
Synonyms: ICN-1229, NSC-163039, Tribavirin, RTCA

Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.

Ribavirin, CAS 36791-04-5
Pack Size Availability Price/USD Quantity
25 mg In stock 34.00
50 mg In stock 45.00
100 mg In stock 54.00
200 mg In stock 89.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 99.09%
Purity 99.83%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
Targets&IC50 ADK ,   IMPDH1 ,   RNA polymerase
Cell Research
The effect of Ribavirin on microglial cell viability is evaluated by the sulforhodamine B (SRB) chemosensitivity assay. Briefly, LPS-stimulated microglial cells are incubated for 48 h in the presence or absence of Ribavirin. Afterward, the cells are fixed in 10% (w/v) trichloroacetic acid for 1 h at 4°C, rinsed in tap water and stained with 0.4% (w/v) SRB in 1% acetic acid (100 μL/well) for 30 min at room temperature (RT). The cells are then rinsed three times in 1% acetic acid to remove the unbound stain. The protein bound stain is extracted with 200 μL 10 mM Tris base (pH 10.5) per well. The optical density is read at 540 nm, with correction at 670 nm. The results are presented as percentage of the control (non-stimulated/untreated microglial cells), that is arbitrarily set to 100%.
Synonyms ICN-1229 , NSC-163039 , Tribavirin , RTCA
Purity 99.09%
Molecular Weight 244.2
Formula C8H12N4O5
CAS No. 36791-04-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 24.4 mg/mL (100 mM)

water: 24.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Feld JJ, et al. Nature, 2005, 436(7053), 967-972. 2. Crotty S, et al. Nat Med, 2000, 6(12), 1375-1379. 3. Crotty S, et al. Proc Natl Acad Sci U S A, 2001, 98(12), 6895-6900. 4. Ning Q, et al. J Immunol, 1998, 160(7), 3487-3493. 5. Graci JD et al. Rev Med Virol, 2006, 16(1), 37-48. 6. Refaat B, et al. The effects of pegylated interferon-α and ribavirin on liver and serum concentrations of activin-A and follistatin in normal Wistar rat: a preliminary report. BMC Res Notes. 2015 Jun 26;8:265 7. Abdel-Hamid NM, et al. Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats. Asian Pac J Cancer Prev. 2016;17(4):1979-85. 8. Chen L, Hao Y, Song H, et al. Design, Synthesis, Characterization, and Biological Activities of Novel Spirooxindole Analogues Containing Hydantoin, Thiohydantoin, Urea, and Thiourea Moieties[J]. Journal of Agricultural and Food Chemistry. 2020, 68(39): 10618-10625. 9. Suroengrit A, Yuttithamnon W, Srivarangkul P, et al. Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity[J]. Scientific Reports. 2017 Oct 20;7(1):13696 10. Srivarangkul P, Yuttithamnon W, Suroengrit A, et al. A novel flavanone derivative inhibits dengue virus fusion and infectivity[J]. Antiviral research. 2018 Mar;151:27-38.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Anti-infection Compound Library Neuronal Signaling Compound Library Epigenetics Compound Library Anti-virus Compound Library FDA-approved Drug Library Immunology/Inflammation Compound Library DNA Damage & Repair Compound Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Killers Collection CNS-Penetrant Compound Library Anti-aging Compound Library Anti-cancer Drug library Drug Repurposing Library Neurotransmitter Receptor Compound Library Anti-COVID-19 Compound Library Nucleotide Compound Library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library

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