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Ribavirin

Catalog No. T0684 CAS 36791-04-5

Synonyms: ICN-1229, Tribavirin, NSC-163039, RTCA

Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ribavirin, CAS 36791-04-5

Pack Size	Availability	Price/USD
50 mg	In stock	$ 39.00
100 mg	In stock	$ 48.00
200 mg	In stock	$ 78.00
500 mg	In stock	$ 163.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.83%

Purity: 99.82%

Purity: 99.09%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
In vivo	ALT, AST activities and bilirubin levels are significantly loared by administration of JAT in combination with interferon and ribavirin (p<0.01). JAT, interferon or ribavirin alone with CCl4, livers appear to exhibit some liver protection against CCl4 as evident by the presence of normal hepatic cords, absence of necrosis and lesser fatty infiltration. Groups treated with JAT, Peg-interferon and ribavirin separately or in combination shows reduction in the expression of TGF- β and Bax. In the group treated by triple combination of interferon, ribavirin, and JAT, the expression level of p53 is markedly reduced[6]. Ribavirin capsules (400 mg of ribavirin)-treated Wistar rats show a significant decrease in activin-A and significant increase in follistatin at the serum and liver levels. Ribavirin has strong antiviral activity only when ribavirin is combined with either IFN-α or Peg-IFN-α[7]. Ribavirin (40 mg/kg, p.o.) significantly improves the antiviral efficacy of CM-10-18 in mice. Ribavirin inhibits DENV virus infection in cultured cells, but it is ineffective in reducing viremia in monotherapy[8].
Cell Research	The effect of Ribavirin on microglial cell viability is evaluated by the sulforhodamine B (SRB) chemosensitivity assay. Briefly, LPS-stimulated microglial cells are incubated for 48 h in the presence or absence of Ribavirin. Afterward, the cells are fixed in 10% (w/v) trichloroacetic acid for 1 h at 4°C, rinsed in tap water and stained with 0.4% (w/v) SRB in 1% acetic acid (100 μL/well) for 30 min at room temperature (RT). The cells are then rinsed three times in 1% acetic acid to remove the unbound stain. The protein bound stain is extracted with 200 μL 10 mM Tris base (pH 10.5) per well. The optical density is read at 540 nm, with correction at 670 nm. The results are presented as percentage of the control (non-stimulated/untreated microglial cells), that is arbitrarily set to 100%.

Synonyms	ICN-1229, Tribavirin, NSC-163039, RTCA
Molecular Weight	244.2
Formula	C8H12N4O5
CAS No.	36791-04-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: 24.4 mg/mL (100 mM)

DMSO: 24.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Feld JJ, et al. Nature, 2005, 436(7053), 967-972. 2. Crotty S, et al. Nat Med, 2000, 6(12), 1375-1379. 3. Crotty S, et al. Proc Natl Acad Sci U S A, 2001, 98(12), 6895-6900. 4. Ning Q, et al. J Immunol, 1998, 160(7), 3487-3493. 5. Graci JD et al. Rev Med Virol, 2006, 16(1), 37-48. 6. Refaat B, et al. The effects of pegylated interferon-α and ribavirin on liver and serum concentrations of activin-A and follistatin in normal Wistar rat: a preliminary report. BMC Res Notes. 2015 Jun 26;8:265 7. Abdel-Hamid NM, et al. Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats. Asian Pac J Cancer Prev. 2016;17(4):1979-85. 8. Chen L, Hao Y, Song H, et al. Design, Synthesis, Characterization, and Biological Activities of Novel Spirooxindole Analogues Containing Hydantoin, Thiohydantoin, Urea, and Thiourea Moieties[J]. Journal of Agricultural and Food Chemistry. 2020, 68(39): 10618-10625. 9. Suroengrit A, Yuttithamnon W, Srivarangkul P, et al. Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity[J]. Scientific Reports. 2017 Oct 20;7(1):13696 10. Srivarangkul P, Yuttithamnon W, Suroengrit A, et al. A novel flavanone derivative inhibits dengue virus fusion and infectivity[J]. Antiviral research. 2018 Mar;151:27-38.

Citations

1. Xu W, Yang R, Hao Y, et al. Discovery of Aldisine and Its Derivatives as Novel Antiviral, Larvicidal, and Antiphytopathogenic-Fungus Agents. Journal of Agricultural and Food Chemistry. 2022 2. Cheng N, Jiang N, Fu Y, et al. The mechanism and pharmacodynamics of 2-((1H-indol-3-yl) thio/sulfinyl)-N-pheny acetamide derivative as a novel inhibitor against human respiratory syncytial virus. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022, 37(1): 2598-2604 3. Suroengrit A, Yuttithamnon W, Srivarangkul P, et al. Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity. Scientific Reports. 2017, 7(1): 1-11 4. Cui P, Cai M, Meng Y, et al. Design, synthesis and biological activities of echinopsine derivatives containing acylhydrazone moiety. Scientific Reports. 2022, 12(1): 1-10. 5. Srivarangkul P, Yuttithamnon W, Suroengrit A, et al. A novel flavanone derivative inhibits dengue virus fusion and infectivity. Antiviral Research. 2018 Mar;151:27-38 6. Chen L, Hao Y, Song H, et al. Design, Synthesis, Characterization, and Biological Activities of Novel Spirooxindole Analogues Containing Hydantoin, Thiohydantoin, Urea, and Thiourea Moieties. Journal of Agricultural and Food Chemistry. 2020, 68(39): 10618-10625. 7. Kanyaboon P, Saelee T, Suroengrit A, et al. Cardol triene inhibits dengue infectivity by targeting kl loops and preventing envelope fusion. Scientific Reports. 2018 Nov 9;8(1):16643 8. Fu Y H, Xu Z X, Jiang N, et al. High-throughput screening of active compounds against human respiratory syncytial virus. Virology. 2019 9. Fu Y H, Xu Z X, Jiang N, et al. High-throughput screening of active compounds against human respiratory syncytial virus. Virology. 2019 10. Xu W, Yang R, Liu L, et al.Design, Synthesis, and Bioactivity of Aldisine Derivatives Containing Oxime and Hydrazine Moieties Based on Hydrogen Bonds.Journal of Agricultural and Food Chemistry.2023

Related compound libraries

This product is contained In the following compound libraries：

Toxic Compound Library Drug-Fragment Library Anti-Liver Cancer Compound Library Neuronal Signaling Compound Library NO PAINS Compound Library NMPA-Approved Drug Library Anti-COVID-19 Compound Library ReFRAME Related Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Clinical Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ribavirin 36791-04-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Microbiology/Virology Neuroscience Proteases/Proteasome Dehydrogenase HCV Protease DNA/RNA Synthesis Antibiotic AChR RSV ICN-1229 Respiratory syncytial virus ICN 1229 Inhibitor HCV inhibit ICN1229 Tribavirin Orthopoxvirus NSC-163039 RTCA Hepatitis C virus inhibitor

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