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Retrorsine

Catalog No. TN2147 CAS 480-54-6

Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.

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Retrorsine, CAS 480-54-6

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2 mg	5 days	$ 109.00

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Description	Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
Targets&IC50	OCT1:2.2 μM
In vitro	Retrorsine inhibited the OCT1-mediated 1-methyl-4-phenylpyridinium (MPP(+)) uptake in MDCK-hOCT1 cells with the IC50 of 2.25±0.30μM[1]. Retrorsine (60 μM, 120 μM , 240 μM; 24 h) significantly reduced HSEC-CYP3A4 cell viability and GSH levels and increases the formation of pyrrole-protein adducts[2].
In vivo	In male Wistar rats, Retrorsine (30 mg/kg; i.p.; twice) impaired liver regeneration in the PBL model not only by an S or G2/M phase block but also by a block located before the G1/S transition of the cell cycle[3].
Source	Natural Products > Asteraceae > Senecio

Molecular Weight	351.39
Formula	C18H25NO6
CAS No.	480-54-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (270.35 mM), Sonification is recommended.

References and Literature

1. Tu M, et al. Involvement of organic cation transporter 1 and CYP3A4 in retrorsine-induced toxicity. Toxicology. 2014 Aug 1;322:34-42. 2. Yao Lu, et al. Establishment of a novel CYP3A4-transduced human hepatic sinusoidal endothelial cell model and its application in screening hepatotoxicity of pyrrolizidine alkaloids. J Environ Sci Health C Toxicol Carcinog. 2020;38(2):169-185. 3. Christian Picard, et al. Retrorsine: a kinetic study of its influence on rat liver regeneration in the portal branch ligation model. J Hepatol. 2003 Jul;39(1):99-105. 4. F J Cubero, et al. Hepatic proliferation in Gunn rats transplanted with hepatocytes: effect of retrorsine and tri-iodothyronine. Cell Prolif. 2005 Jun;38(3):137-46.

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Keywords

Retrorsine 480-54-6 Membrane transporter/Ion channel Metabolism OCT P450 pyrrolizidine inhibit hepatotoxic hepatocellular Inhibitor injury alkaloid inhibitor

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