Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Reldesemtiv (CK-2127107) is a selective activator of fast skeletal muscle troponin with an EC50 of 3.4 μM. Reldesemtiv increases exercise performance in the heart failure model.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 187.00 | |
5 mg | In stock | $ 397.00 | |
10 mg | In stock | $ 589.00 | |
25 mg | In stock | $ 945.00 | |
50 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 437.00 |
Description | Reldesemtiv (CK-2127107) is a selective activator of fast skeletal muscle troponin with an EC50 of 3.4 μM. Reldesemtiv increases exercise performance in the heart failure model. |
In vitro | Reldesemtiv selectively binds to the fast skeletal troponin complex and sensitizes to calcium [1]. |
In vivo | Reldesemtiv increases sarcomeric Ca2+ sensitivity in skinned LAD-HF skeletal fibers. In exercise-intolerant LAD-HF rats, Reldesemtiv (10 mg/kg; p.o.) obviously improves rotarod performance. Reldesemtiv (10 mg/kg; i.v.) enhances Ca2+ sensitivity in fast skeletal muscle fibers and increases muscle force in response to submaximal stimulation frequencies[1]. |
Synonyms | CK-2127107 |
Molecular Weight | 384.38 |
Formula | C19H18F2N6O |
CAS No. | 1345410-31-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225 mg/mL (585.4 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Reldesemtiv 1345410-31-2 Others CK 2127107 CK-2127107 CK2127107 inhibitor inhibit