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RGD

Catalog No. T6966 CAS 99896-85-2

Synonyms: RGD (Arg-Gly-Asp) Peptides, Arg-Gly-Asp, RGD Peptides

RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.

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RGD, CAS 99896-85-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 54.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 155.00
50 mg	In stock	$ 279.00
100 mg	In stock	$ 437.00

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Purity: 99.11%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.

In vitro

The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides and mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, and cancer. [1] RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. [2] The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. [3] In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion. [4]

Synonyms	RGD (Arg-Gly-Asp) Peptides, Arg-Gly-Asp, RGD Peptides
Molecular Weight	346.34
Formula	C12H22N6O6
CAS No.	99896-85-2

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 34.6 mM

References and Literature

1. Ruoslahti E, et al. Annu Rev Cell Dev Biol, 1996, 12, 697-715. 2. Buckley CD, et al. Nature, 1999, 397(6719), 534-539. 3. Meredith JE Jr, et al. Trends Cell Biol, 1997, 7(4), 146-150. 4. Yang W, et al. J Biol Chem, 1999, 274(13), 8524-8530.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Apoptosis Compound Library ReFRAME Related Library NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RGD 99896-85-2 Cytoskeletal Signaling Integrin RGD (Arg-Gly-Asp) Peptides inhibit Inhibitor Arg-Gly-Asp RGD Peptides inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.