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RG14620

Catalog No. T3554 CAS 136831-49-7

Synonyms: Tyrphostin RG14620, RG 14620

RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RG14620, CAS 136831-49-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 30.00
5 mg	In stock	$ 48.00
10 mg	In stock	$ 70.00
25 mg	In stock	$ 139.00
50 mg	In stock	$ 272.00
100 mg	In stock	$ 455.00
500 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 99.79%

Purity: 99.56%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.
Targets&IC50	EGFR:3 μM.
In vitro	RG-14620 inhibits colony formation and DNA synthesis by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC50s for RG-14620 are 3 μM for HER 14 colony formation and 1 pM for HER 14 DNA synthesis[1]. RG-14620 also suppresses colony formation and DNA synthesis by EGF-stimulated MH-85 cells in a dose-dependent manner. The IC50s for RG-14620 on MH-85 cells are 4 μM for colony formation and 1.25 μM for DNA synthesis[1].
In vivo	RG-14620, at a dose of 200 μg/mouse/day inhibits MH-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals[1].
Cell Research	RG14620 is dissolved in 100% DMSO and diluted with the culture medium before addition to the cells. MH-85 and HER 14 cells are cultured in the medium in the presence or absence of increasing concentrations of RG-13022 or RG-14620 for 10 days. At the end of culture, the cells are fixed with 4% (v/v) formaldehyde in calcium-magnesium-free phosphate-buffered saline for 15 min at room temperature and stained with hematoxylin. Numbers of colonies including more than 20 cells in each well are counted under the microscope[1].

Synonyms	Tyrphostin RG14620, RG 14620
Molecular Weight	275.13
Formula	C14H8Cl2N2
CAS No.	136831-49-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 18.33 mg/mL (66.64 mM)

References and Literature

1. Yoneda T, et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51(16):4430-5.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Inhibitor Library Kinase Inhibitor Library Anti-Breast Cancer Compound Library Immunology/Inflammation Compound Library NO PAINS Compound Library Anti-Colorectal Cancer Compound Library Anti-Prostate Cancer Compound Library Angiogenesis related Compound Library

Related Products

Related compounds with same targets

EAI001 Mutated EGFR-IN-1 WZ4002 Tucatinib EGFR-IN-82 Selatinib PD153035 hydrochloride Norcantharidin

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RG14620 136831-49-7 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER Tyrphostin RG-14620 HER1 inhibit RG-14620 Tyrphostin RG14620 RG 14620 Tyrphostin RG 14620 Inhibitor Epidermal growth factor receptor ErbB-1 inhibitor

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