Pyrithioxin dihydrochloride (Pyrithioxine HCl) has anti-nociceptive and anti-allodynic effects, can promote the metabolism of glucose and amino acids in the brain, improve systemic assimilation, and can be used to study neurological diseases such as atherosclerosis. Pyrithioxin dihydrochloride can induce severe cholestatic hepatitis.

METHODS: The effect of Pyrithioxin dihydrochloride on children with learning disabilities was tested under strict double-blind conditions in 67 students in a class with learning disabilities aged 11 to 16 years who received either Pyrithioxin dihydrochloride (300 mg, 24 hours) or placebo for 6 months. Effects on cognitive function.
RESULTS:Pyrithioxin dihydrochloride had different effects on different subjects. None of the 22 parameters showed a statistically significant treatment effect in terms of mean performance. Variability was significantly higher in the Pyrithioxin dihydrochloride group (F = 1.85-2.33, P less than 0.05 and less than 0.02, respectively). [1]