Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Purpurogallin is a naturally phenol extracted from the plants of Quercus spp. It has effective xanthine oxidase inhibitory activity (IC50: 0.2 μM). Purpurogallin also has antioxidant and anti-inflammatory effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 48.00 | |
10 mg | In stock | $ 82.00 | |
25 mg | In stock | $ 124.00 | |
50 mg | In stock | $ 166.00 | |
100 mg | In stock | $ 249.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 56.00 |
Description | Purpurogallin is a naturally phenol extracted from the plants of Quercus spp. It has effective xanthine oxidase inhibitory activity (IC50: 0.2 μM). Purpurogallin also has antioxidant and anti-inflammatory effects. |
Targets&IC50 | XO:0.2 μM |
In vitro | Purpurogallin (100 μM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells. Purpurogallin (50 or 100 μM; 7 or 25 hours; BV2 murine microglial cells) treatment decreases the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells[1]. |
In vivo | By the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression, Purpurogallin (100-400?μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect [2]. |
Molecular Weight | 220.18 |
Formula | C11H8O5 |
CAS No. | 569-77-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (567.72 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Purpurogallin 569-77-7 Metabolism Xanthine Oxidase Inhibitor inhibit inhibitor